HitPredict

Interactor 1: CALX (P27824)
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene: CANX

Interactor 2: RTN4 (Q9NQC3)
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
Gene: RTN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29568061, 35271311
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 1192
+	Hs
		306984 CALX_HUMAN (1-592): 0: 786: 100.00		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06
+	Hs
		258902 CALX_HUMAN (1-592): 0: 786: 100.00		RTN2_HUMAN (775-1185): 4.86e-44: 171: 25.39
+	Hs
		653737 CALR_HUMAN (67-470): 1.19e-141: 418: 38.33		RTN4_HUMAN (1-1192): 3.85e-113: 383: 100.00
+	Dm
		667060 CALR_DROME (65-480): 9.62e-132: 393: 33.89		Q9VMW2_DROME (1000-1192): 3.24e-71: 238: 49.74
+	Hs
		306983 CALR_HUMAN (67-470): 1.19e-141: 418: 38.33		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06
+	Dm
		667059 CALR_DROME (65-480): 9.62e-132: 393: 33.89		Q9VMV9_DROME (731-1192): 5.95e-64: 230: 25.43
+	Hs
		258901 CALR_HUMAN (67-470): 1.19e-141: 418: 38.33		RTN2_HUMAN (775-1185): 4.86e-44: 171: 25.39