HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	15699045, 11226259, 17620599
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 360 Hs			1 409
+	Hs
		647481 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		658850 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		647514 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Dm
		772970 ERKA_DROME (3-357): 2.75e-151: 432: 79.44		Q9V393_DROME (3-402): 0: 594: 57.48
+	Hs
		827213 MK14_HUMAN (18-356): 7.86e-112: 332: 48.97		ARRB1_HUMAN (1-407): 0: 661: 76.15