Protein: PTPRC
Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)

Gene: PTPRC
Organism: Homo sapiens
Interactions: 62
UniProt ID: P08575

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000165 - MAPK cascade
GO:0001779 - natural killer cell differentiation
GO:0001915 - negative regulation of T cell mediated cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439910

LCK
Tyrosine-protein kinase Lck

9

20

Small-scale

0.975

High

471744

GANAB
Neutral alpha-glucosidase AB

3

4

Small-scale

0.876

High

471709

PTPRC
Receptor-type tyrosine-protein phosphatase C

2

19

Small-scale

0.793

High

471721

CD22
B-cell receptor CD22

2

13

Small-scale

0.754

High

471750

SEM4D
Semaphorin-4D

2

2

Small-scale

0.754

High

471728

MK01
Mitogen-activated protein kinase 1

1

11

Small-scale

0.747

High

362628

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.726

High

463284

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.724

High

471752

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

1

Small-scale

0.724

High

471732

CSK
Tyrosine-protein kinase CSK

2

20

Small-scale

0.712

High

440304

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.647

High

445471

CD2
T-cell surface antigen CD2

1

18

Small-scale

0.647

High

471715

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

471714

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

1

Small-scale

0.618

High

471717

CD1D
Antigen-presenting glycoprotein CD1d

1

9

Small-scale

0.618

High

471731

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

1

Small-scale

0.618

High

471746

MK14
Mitogen-activated protein kinase 14

1

11

Small-scale

0.618

High

471747

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.618

High

471755

PLK3
Serine/threonine-protein kinase PLK3

1

4

Small-scale

0.618

High

378816

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.614

High

378897

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

0

Small-scale

0.614

High

471711

LEG1
Galectin-1

2

20

Small-scale

0.611

High

471745

PTCA
Protein tyrosine phosphatase receptor type C-associated protein

2

1

Small-scale

0.595

High

193487

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

High-throughput

0.575

High

410537

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

411217

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.575

High

439622

INSR
Insulin receptor

1

20

High-throughput

0.575

High

471710

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.575

High

471712

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.575

High

471713

GHR
Growth hormone receptor

1

20

High-throughput

0.575

High

471718

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

4

Small-scale

0.575

High

471720

EPOR
Erythropoietin receptor

1

20

High-throughput

0.575

High

471724

CBL
E3 ubiquitin-protein ligase CBL

1

10

High-throughput

0.575

High

471726

MK03
Mitogen-activated protein kinase 3

1

11

High-throughput

0.575

High

471730

TIE1
Tyrosine-protein kinase receptor Tie-1

1

20

High-throughput

0.575

High

471733

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.575

High

471736

LEPR
Leptin receptor

1

20

High-throughput

0.575

High

471739

TIE2
Angiopoietin-1 receptor

1

20

High-throughput

0.575

High

471740

ACK1
Activated CDC42 kinase 1

1

20

High-throughput

0.575

High

471722

ITAL
Integrin alpha-L

1

9

Small-scale

0.573

High

471729

CTNB1
Catenin beta-1

2

20

Small-scale

0.571

High

471748

SKAP1
Src kinase-associated phosphoprotein 1

1

15

Small-scale

0.552

High

471723

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

1

Small-scale

0.501

High

210689

KLK10
Kallikrein-10

1

10

High-throughput

0.489

High

471757

RNF11
RING finger protein 11

1

8

High-throughput

0.481

High

471727

DPP4
Dipeptidyl peptidase 4

1

2

Small-scale

0.479

High

471738

CXCR4
C-X-C chemokine receptor type 4

1

6

Small-scale

0.479

High

471742

SLAF1
Signaling lymphocytic activation molecule

1

16

Small-scale

0.479

High

471719

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

471734

WASP
Actin nucleation-promoting factor WAS

1

6

High-throughput

0.445

High

471735

NSF
Vesicle-fusing ATPase

1

9

High-throughput

0.445

High

471737

PAXI
Paxillin

1

11

High-throughput

0.445

High

471741

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

9

High-throughput

0.445

High

471743

GAB1
GRB2-associated-binding protein 1

1

8

High-throughput

0.445

High

471753

PKP4
Plakophilin-4

1

20

High-throughput

0.445

High

471754

CD244
Natural killer cell receptor 2B4

1

14

Small-scale

0.445

High

471716

GLU2B
Glucosidase 2 subunit beta

1

3

Small-scale

0.437

High

471756

FBX6
F-box only protein 6

1

9

High-throughput

0.437

High

471749

CD177
CD177 antigen

1

0

Small-scale

0.426

High

471751

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

471725

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025