HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: SRBP2 (Q12772)
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
Gene: SREBF2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	10627507, 14988395
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 360 Hs			1 1141
+	Hs
		647557 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		SRBP2_HUMAN (1-1141): 0: 1168: 100.00
+	Hs
		658820 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		SRBP1_HUMAN (1-1141): 0: 870: 43.72
+	Hs
		647489 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		SRBP1_HUMAN (1-1141): 0: 870: 43.72
+	Hs
		659020 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		CBP_HUMAN (5-492): 1.07e-29: 130: 12.88
+	Hs
		647643 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		CBP_HUMAN (5-492): 1.07e-29: 130: 12.88
+	Hs
		647613 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		MCAF1_HUMAN (17-480): 6.91e-28: 124: 12.42
+	Hs
		658910 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		EP300_HUMAN (13-430): 1.85e-13: 77.7: 8.50
+	Hs
		998769 MK14_HUMAN (18-356): 7.86e-112: 332: 48.97		EP300_HUMAN (13-430): 1.85e-13: 77.7: 8.50
+	Hs
		1082593 MK14_HUMAN (18-356): 7.86e-112: 332: 48.97		KMT2C_HUMAN (15-528): 4.71e-13: 76.5: 10.09