HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: DUS16 (Q9BY84)
Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7)
Gene: DUSP16

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	11489891, 11359773
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 665
+	Hs
		658923 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS8_HUMAN (8-665): 1.34e-158: 472: 43.51
+	Hs
		658798 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS1_HUMAN (10-382): 1.47e-108: 334: 27.95
+	Hs
		647475 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS1_HUMAN (10-382): 1.47e-108: 334: 27.95
+	Hs
		658903 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS2_HUMAN (6-299): 2.29e-105: 324: 35.28
+	Mm
		926403 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS2_MOUSE (7-299): 6.16e-103: 318: 35.71
+	Mm
		926439 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS6_MOUSE (2-323): 1.75e-100: 314: 29.95
+	Hs
		658919 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS4_HUMAN (8-382): 5.3e-100: 313: 27.67
+	Rn
		926496 MK01_RAT (10-360): 4.96e-158: 449: 99.72		DUS6_RAT (2-323): 1.93e-100: 313: 29.95
+	Hs
		658961 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS6_HUMAN (2-323): 3.05e-99: 310: 30.22
+	Hs
		658960 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS5_HUMAN (5-360): 2.57e-97: 306: 27.60
+	Hs
		658962 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS7_HUMAN (11-320): 5.24e-97: 306: 30.31
+	Hs
		659102 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS10_HUMAN (6-311): 1.76e-88: 286: 32.10
+	Hs
		659034 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS9_HUMAN (11-341): 6.13e-81: 263: 25.52
+	Hs
		56510 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		PTPC1_HUMAN (119-620): 2.99e-76: 261: 13.67
+	Hs
		56508 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		PTPC1_HUMAN (119-620): 2.99e-76: 261: 13.67
+	Hs
		659090 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS12_HUMAN (135-387): 2.87e-60: 207: 23.26
+	Hs
		659006 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS19_HUMAN (162-296): 8.79e-58: 196: 33.33
+	Hs
		659008 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		STYX_HUMAN (141-323): 5.07e-57: 194: 27.46
+	Hs
		658858 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS3_HUMAN (151-301): 1.1e-53: 183: 30.00
+	Hs
		647521 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS3_HUMAN (151-301): 1.1e-53: 183: 30.00