HitPredict

Interactor 1: DEST (P60981)
Destrin (Actin-depolymerizing factor) (ADF)
Gene: DSTN

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005737 - cytoplasm GO:0015629 - actin cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 165 Hs			1 377
+	Hs
		660089 COF1_HUMAN (1-165): 5.15e-70: 210: 71.08		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		955819 DEST_HUMAN (1-165): 6.08e-74: 220: 100.00		ACTS_HUMAN (1-377): 0: 595: 97.88
+	Hs
		952697 DEST_HUMAN (1-165): 6.08e-74: 220: 100.00		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		955818 DEST_HUMAN (1-165): 6.08e-74: 220: 100.00		ACTG_HUMAN (4-377): 0: 594: 94.39
+	Hs
		955834 DEST_HUMAN (1-165): 6.08e-74: 220: 100.00		Q1KLZ0_HUMAN (4-377): 0: 594: 94.12
+	Mm
		616470 COF1_MOUSE (1-165): 2.58e-70: 211: 71.08		ACTB_MOUSE (4-377): 0: 594: 94.12
+	Hs
		660031 COF1_HUMAN (1-165): 5.15e-70: 210: 71.08		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Hs
		660032 COF1_HUMAN (1-165): 5.15e-70: 210: 71.08		ACTS_HUMAN (1-377): 0: 595: 97.88
+	Hs
		995907 COF2_HUMAN (1-165): 4.18e-70: 210: 68.68		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Hs
		1168811 Q549N0_HUMAN (1-165): 4.18e-70: 210: 68.68		Q1KLZ0_HUMAN (4-377): 0: 594: 94.12
+	Hs
		660017 COF1_HUMAN (1-165): 5.15e-70: 210: 71.08		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		660028 COF1_HUMAN (1-165): 5.15e-70: 210: 71.08		ACTG_HUMAN (4-377): 0: 594: 94.39
+	Hs
		660081 COF1_HUMAN (1-165): 5.15e-70: 210: 71.08		Q1KLZ0_HUMAN (4-377): 0: 594: 94.12
+	Rn
		852477 COF1_RAT (1-165): 4.82e-70: 210: 71.08		ACTB_RAT (4-377): 0: 594: 94.12
+	Hs
		952874 Q549N0_HUMAN (1-165): 4.18e-70: 210: 68.68		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		953195 COF2_HUMAN (1-165): 4.18e-70: 210: 68.68		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		993207 Q549N0_HUMAN (1-165): 4.18e-70: 210: 68.68		ACTG_HUMAN (4-377): 0: 594: 94.39
+	Hs
		993390 COF2_HUMAN (1-165): 4.18e-70: 210: 68.68		ACTG_HUMAN (4-377): 0: 594: 94.39
+	Hs
		660025 COF1_HUMAN (1-165): 5.15e-70: 210: 71.08		ACTA_HUMAN (1-377): 0: 593: 100.00
+	Hs
		660029 COF1_HUMAN (1-165): 5.15e-70: 210: 71.08		ACTH_HUMAN (4-377): 0: 587: 99.20