HitPredict

Interactor 1: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28514442, 38334954
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0015629 - actin cytoskeleton GO:0016020 - membrane GO:0070062 - extracellular exosome and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 376
+	Mm
		616470 COF1_MOUSE (1-166): 1.36e-72: 217: 98.80		ACTB_MOUSE (3-376): 0: 595: 91.71
+	Rn
		852477 COF1_RAT (1-166): 3.12e-72: 216: 99.40		ACTB_RAT (3-376): 0: 595: 91.71
+	Hs
		660017 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		660081 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		Q1KLZ0_HUMAN (3-376): 0: 595: 91.71
+	Hs
		1168811 Q549N0_HUMAN (1-166): 1.69e-71: 214: 80.72		Q1KLZ0_HUMAN (3-376): 0: 595: 91.71
+	Hs
		660028 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		952874 Q549N0_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		953195 COF2_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		993207 Q549N0_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		993390 COF2_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		660029 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTH_HUMAN (1-376): 0: 589: 87.77
+	Hs
		660031 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		660032 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTS_HUMAN (2-376): 0: 588: 87.47
+	Hs
		952697 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		955834 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		Q1KLZ0_HUMAN (3-376): 0: 595: 91.71
+	Hs
		995907 COF2_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		955818 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		660025 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTA_HUMAN (1-376): 0: 586: 87.80
+	Hs
		955819 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		ACTS_HUMAN (2-376): 0: 588: 87.47
+	Hs
		955817 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		ACTA_HUMAN (1-376): 0: 586: 87.80