HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: COF2 (Q9Y281)
Cofilin-2 (Cofilin, muscle isoform)
Gene: CFL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	30890647
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0015629 - actin cytoskeleton GO:0031674 - I band GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 166
+	Hs
		1168811 Q1KLZ0_HUMAN (4-377): 0: 598: 94.12		Q549N0_HUMAN (1-166): 1.39e-73: 219: 100.00
+	Hs
		660031 ACTC_HUMAN (1-377): 0: 599: 100.00		COF1_HUMAN (1-166): 3.76e-73: 218: 80.72
+	Hs
		660032 ACTS_HUMAN (1-377): 0: 599: 98.94		COF1_HUMAN (1-166): 3.76e-73: 218: 80.72
+	Hs
		993207 ACTG_HUMAN (4-377): 0: 598: 94.39		Q549N0_HUMAN (1-166): 1.39e-73: 219: 100.00
+	Hs
		993390 ACTG_HUMAN (4-377): 0: 598: 94.39		COF2_HUMAN (1-166): 1.39e-73: 219: 100.00
+	Hs
		660017 ACTB_HUMAN (4-377): 0: 598: 94.12		COF1_HUMAN (1-166): 3.76e-73: 218: 80.72
+	Hs
		660028 ACTG_HUMAN (4-377): 0: 598: 94.39		COF1_HUMAN (1-166): 3.76e-73: 218: 80.72
+	Hs
		660081 Q1KLZ0_HUMAN (4-377): 0: 598: 94.12		COF1_HUMAN (1-166): 3.76e-73: 218: 80.72
+	Hs
		955819 ACTS_HUMAN (1-377): 0: 599: 98.94		DEST_HUMAN (1-166): 2.98e-69: 208: 68.68
+	Hs
		952697 ACTB_HUMAN (4-377): 0: 598: 94.12		DEST_HUMAN (1-166): 2.98e-69: 208: 68.68
+	Hs
		955818 ACTG_HUMAN (4-377): 0: 598: 94.39		DEST_HUMAN (1-166): 2.98e-69: 208: 68.68
+	Hs
		955834 Q1KLZ0_HUMAN (4-377): 0: 598: 94.12		DEST_HUMAN (1-166): 2.98e-69: 208: 68.68
+	Sp
		534533 ACT_SCHPO (4-377): 0: 645: 89.04		COFI_SCHPO (3-151): 8.62e-46: 148: 32.22
+	At
		920960 ACT11_ARATH (1-377): 0: 618: 88.33		ADF6_ARATH (3-152): 4.39e-48: 154: 28.48
+	Hs
		995558 ACTC_HUMAN (1-377): 0: 599: 100.00		TWF1_HUMAN (3-156): 3.6e-33: 121: 21.66
+	Hs
		993148 ACTG_HUMAN (4-377): 0: 598: 94.39		TWF1_HUMAN (3-156): 3.6e-33: 121: 21.66
+	Ce
		534403 ACT4_CAEEL (1-377): 0: 600: 94.43		ADF1_CAEEL (1-149): 2.85e-32: 116: 29.09
+	Hs
		955875 ACTG_HUMAN (4-377): 0: 598: 94.39		GMFB_HUMAN (1-154): 2.31e-33: 116: 19.11
+	Hs
		995646 ACTC_HUMAN (1-377): 0: 599: 100.00		TWF2_HUMAN (3-151): 2.44e-29: 111: 18.42
+	Hs
		993215 ACTG_HUMAN (4-377): 0: 598: 94.39		TWF2_HUMAN (3-151): 2.44e-29: 111: 18.42