HitPredict

Interactor 1: PSB6 (P23724)
Proteasome subunit beta type-6 (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5)
Gene: PRE7

Interactor 2: RPN11 (P43588)
Ubiquitin carboxyl-terminal hydrolase RPN11 (EC 3.4.19.12) (26S proteasome regulatory subunit RPN11) (Protein MPR1)
Gene: RPN11

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.747

Property	Details
Experiments	22215586, 24038880, 37968396, 31848235, 30792173, 15917626, 21321079, 21627799, 21658604, 22927375
Identification Methods	biochemical, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 241 Sc			1 306
+	Dm
		1376917 PSA5_DROME (7-241): 5.35e-72: 221: 18.70		PSDE_DROME (1-306): 6.82e-103: 305: 64.29
+	Hs
		138044 PSA6_HUMAN (6-241): 7.1e-75: 228: 18.75		PSDE_HUMAN (16-306): 2.54e-98: 293: 67.35
+	Hs
		137864 PSA7_HUMAN (6-241): 1.67e-73: 225: 18.75		PSDE_HUMAN (16-306): 2.54e-98: 293: 67.35
+	Hs
		137969 PSA4_HUMAN (6-240): 6.64e-73: 224: 16.32		PSDE_HUMAN (16-306): 2.54e-98: 293: 67.35
+	Hs
		137974 PSA5_HUMAN (7-241): 3.59e-72: 222: 17.21		PSDE_HUMAN (16-306): 2.54e-98: 293: 67.35
+	Sp
		836457 PSA5_SCHPO (7-240): 6.46e-73: 223: 18.85		RPN11_SCHPO (1-305): 3.12e-95: 285: 64.29
+	Sp
		836459 PSB3_SCHPO (25-241): 2.16e-72: 221: 23.74		RPN11_SCHPO (1-305): 3.12e-95: 285: 64.29
+	Hs
		137956 PSB1_HUMAN (10-241): 1.21e-67: 210: 44.83		PSDE_HUMAN (16-306): 2.54e-98: 293: 67.35
+	Sp
		836443 PSA3_SCHPO (6-236): 1.59e-70: 217: 15.32		RPN11_SCHPO (1-305): 3.12e-95: 285: 64.29
+	Sp
		836452 PSB6_SCHPO (18-241): 1.59e-70: 217: 55.80		RPN11_SCHPO (1-305): 3.12e-95: 285: 64.29
+	Sc
		675254 PSB3_YEAST (22-241): 4.15e-67: 207: 22.87		RPN11_YEAST (1-306): 4.61e-91: 274: 100.00
+	Hs
		954872 PSA6_HUMAN (6-241): 7.1e-75: 228: 18.75		CSN5_HUMAN (14-292): 7.27e-75: 234: 30.74
+	Hs
		165389 PSA7_HUMAN (6-241): 1.67e-73: 225: 18.75		CSN5_HUMAN (14-292): 7.27e-75: 234: 30.74
+	At
		842094 PSB1_ARATH (21-241): 1.73e-67: 209: 43.89		CSN5A_ARATH (5-295): 4.04e-75: 235: 29.26
+	Sc
		662059 PSB6_YEAST (1-241): 1.51e-74: 227: 100.00		RPN8_YEAST (25-305): 6.71e-51: 172: 16.03
+	Dm
		684553 PSA5_DROME (7-241): 5.35e-72: 221: 18.70		PSMD7_DROME (23-305): 1.04e-43: 154: 15.57
+	Hs
		906491 PSA6_HUMAN (6-241): 7.1e-75: 228: 18.75		PSMD7_HUMAN (23-149): 5.67e-31: 120: 24.06
+	Hs
		681599 PSA4_HUMAN (6-240): 6.64e-73: 224: 16.32		PSMD7_HUMAN (23-149): 5.67e-31: 120: 24.06
+	Hs
		700584 PSA5_HUMAN (7-241): 3.59e-72: 222: 17.21		PSMD7_HUMAN (23-149): 5.67e-31: 120: 24.06
+	Hs
		633633 PSB1_HUMAN (10-241): 1.21e-67: 210: 44.83		PSMD7_HUMAN (23-149): 5.67e-31: 120: 24.06