HitPredict

Interactor 1: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: UBP39 (Q3TIX9)
Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (U4/U6.U5 tri-snRNP-associated 65 kDa protein)
Gene: Usp39

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37139431
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 489 Mm			1 564
+	Mm
		662976 MDM2_MOUSE (1-489): 0: 673: 100.00		UBP7_MOUSE (25-556): 7.54e-112: 360: 14.21
+	Hs
		1028324 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP7_HUMAN (25-556): 5.13e-113: 363: 14.03
+	Hs
		1028251 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP51_HUMAN (122-558): 1.4e-113: 355: 15.76
+	Hs
		288392 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP2_HUMAN (179-559): 1.01e-112: 349: 21.83
+	Hs
		179749 MDM4_HUMAN (4-488): 0: 560: 31.61		UBP22_HUMAN (122-559): 7.56e-123: 373: 17.39
+	Mm
		205236 MDM4_MOUSE (4-488): 0: 571: 31.69		UBP7_MOUSE (25-556): 7.54e-112: 360: 14.21
+	Hs
		275885 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP12_HUMAN (186-555): 6.09e-92: 288: 17.95
+	Hs
		179733 MDM4_HUMAN (4-488): 0: 560: 31.61		UBP7_HUMAN (25-556): 5.13e-113: 363: 14.03
+	Hs
		179653 MDM4_HUMAN (4-488): 0: 560: 31.61		UBP2_HUMAN (179-559): 1.01e-112: 349: 21.83
+	Hs
		1028400 MDM2_HUMAN (1-488): 0: 636: 80.85		UBP42_HUMAN (224-556): 1.82e-77: 268: 24.42