HitPredict

Interactor 1: 1433Z (P29310)
14-3-3 protein zeta (14-3-3-like protein) (Protein Leonardo)
Gene: 14-3-3zeta

Interactor 2: GRAP (Q08012)
Growth factor receptor-bound protein 2 (Downstream of receptor kinase) (Protein enhancer of sevenless 2B)
Gene: drk

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22028469
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Dm			1 211
+	Hs
		909427 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62
+	Hs
		683253 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62
+	Hs
		646781 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62
+	Dm
		954994 1433E_DROME (4-248): 2.88e-143: 403: 65.18		GRAP_DROME (1-211): 8.97e-63: 195: 100.00
+	Hs
		782766 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		CSK_HUMAN (2-136): 3.18e-25: 103: 36.30
+	Hs
		683181 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		CSK_HUMAN (2-136): 3.18e-25: 103: 36.30
+	Hs
		337416 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43
+	Hs
		789053 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		ABL2_HUMAN (4-138): 3.23e-23: 98.6: 35.71
+	Hs
		337366 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43
+	Hs
		683185 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		ABL2_HUMAN (4-138): 3.23e-23: 98.6: 35.71
+	Hs
		337355 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43
+	Hs
		646706 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		ABL2_HUMAN (4-138): 3.23e-23: 98.6: 35.71
+	Hs
		782768 1433Z_HUMAN (4-248): 3.57e-140: 394: 81.22		CSK_HUMAN (2-136): 3.18e-25: 103: 36.30
+	Hs
		337420 1433Z_HUMAN (4-248): 3.57e-140: 394: 81.22		ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43
+	Hs
		789056 1433Z_HUMAN (4-248): 3.57e-140: 394: 81.22		ABL2_HUMAN (4-138): 3.23e-23: 98.6: 35.71
+	Mm
		910263 1433E_MOUSE (5-246): 4.9e-144: 404: 66.80		CRK_MOUSE (48-209): 2.18e-19: 85.9: 29.17
+	Hs
		646710 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		CRK_HUMAN (48-209): 9e-20: 87: 29.69
+	Mm
		926808 1433Z_MOUSE (4-248): 6.53e-141: 396: 81.63		CRK_MOUSE (48-209): 2.18e-19: 85.9: 29.17
+	Hs
		275184 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		GRAP2_HUMAN (3-56): 7.35e-11: 62.2: 35.19
+	Mm
		910242 1433E_MOUSE (5-246): 4.9e-144: 404: 66.80		SRBS2_MOUSE (160-210): 5.32e-09: 57.3: 39.62