HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 327
+	Hs
		667713 CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		667594 CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		989681 CDK2_MOUSE (1-298): 3.96e-157: 443: 85.26		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Hs
		443290 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		443233 CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		543022 CDK1_MOUSE (1-289): 2.48e-142: 404: 66.21		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Hs
		967666 CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		667754 CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00		PP2AA_HUMAN (8-303): 2.78e-176: 491: 45.79
+	Sp
		410433 CDK1_SCHPO (1-290): 1.05e-136: 390: 65.32		PP11_SCHPO (1-327): 0: 564: 80.73
+	Dm
		559021 CDK2_DROME (1-289): 1.6e-133: 382: 63.67		PP12_DROME (6-303): 0: 546: 88.59
+	Hs
		977464 CDK17_HUMAN (1-296): 1.3e-122: 362: 52.53		PP2AB_HUMAN (8-303): 1.26e-176: 492: 46.13
+	Hs
		977463 CDK16_HUMAN (1-286): 4.12e-107: 322: 55.40		PP2AB_HUMAN (8-303): 1.26e-176: 492: 46.13