HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: NAV2 (Q8IVL1)
Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)
Gene: NAV2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2843 Hs			1 2488
+	Hs
		668653 APC_HUMAN (1-2843): 0: 1286: 100.00		NAV3_HUMAN (1-2488): 0: 839: 49.55
+	Hs
		668666 APC_HUMAN (1-2843): 0: 1286: 100.00		NAV1_HUMAN (494-2488): 6.2e-158: 541: 34.10
+	Hs
		668557 APC_HUMAN (1-2843): 0: 1286: 100.00		SPTB2_HUMAN (59-306): 2.7e-56: 219: 15.54
+	Hs
		174706 APC_HUMAN (1-2843): 0: 1286: 100.00		SPTN2_HUMAN (53-303): 1.61e-54: 214: 15.35
+	Hs
		668757 APC_HUMAN (1-2843): 0: 1286: 100.00		MACF1_HUMAN (31-193): 1.34e-53: 211: 21.69
+	Hs
		668667 APC_HUMAN (1-2843): 0: 1286: 100.00		SYNE1_HUMAN (60-272): 3.79e-53: 210: 19.44
+	Hs
		555607 APC_HUMAN (1-2843): 0: 1286: 100.00		ACTN1_HUMAN (60-244): 1.06e-49: 195: 20.54
+	Dm
		1440737 TITIN_DROME (734-2294): 1.41e-38: 162: 9.18		FLNA_DROME (72-1585): 3.34e-63: 242: 10.75
+	Hs
		547433 ANK2_HUMAN (732-2368): 6.71e-37: 156: 10.07		DMD_HUMAN (82-553): 4.57e-63: 242: 11.37
+	Hs
		1028731 ANK2_HUMAN (732-2368): 6.71e-37: 156: 10.07		SPTB2_HUMAN (59-306): 2.7e-56: 219: 15.54
+	Dm
		1490102 FUTSC_DROME (713-2829): 8.21e-45: 182: 9.87		FUTSC_DROME (329-1822): 4.72e-48: 193: 12.46
+	Hs
		174745 ANK2_HUMAN (732-2368): 6.71e-37: 156: 10.07		SPTN2_HUMAN (53-303): 1.61e-54: 214: 15.35
+	Hs
		1030712 ANK2_HUMAN (732-2368): 6.71e-37: 156: 10.07		MACF1_HUMAN (31-193): 1.34e-53: 211: 21.69
+	Hs
		773767 TITIN_HUMAN (731-2590): 1.4e-32: 142: 7.93		ACTN2_HUMAN (50-246): 1.22e-53: 207: 17.77
+	Hs
		1403962 MUC4_HUMAN (730-2841): 1.62e-72: 274: 11.30		MUC4_HUMAN (594-2006): 2.21e-11: 72.1: 11.35
+	Hs
		555729 TITIN_HUMAN (731-2590): 1.4e-32: 142: 7.93		ACTN1_HUMAN (60-244): 1.06e-49: 195: 20.54
+	Dm
		612396 TITIN_DROME (734-2294): 1.41e-38: 162: 9.18		ACTN_DROME (84-187): 2.94e-29: 130: 29.81
+	Hs
		1061541 TITIN_HUMAN (731-2590): 1.4e-32: 142: 7.93		ACTN3_HUMAN (84-187): 3.78e-31: 136: 29.81
+	Hs
		224763 TITIN_HUMAN (731-2590): 1.4e-32: 142: 7.93		ACTN4_HUMAN (84-187): 1.86e-29: 130: 29.81
+	Hs
		1361879 TITIN_HUMAN (731-2590): 1.4e-32: 142: 7.93		TITIN_HUMAN (260-1845): 2.05e-26: 122: 7.24