HitPredict

Interactor 1: MPIP3 (P30307)
M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)
Gene: CDC25C

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.762

Property	Details
Experiments	27880917, 28330616, 28675297, 11313932, 15284440, 10681541, 15791647, 33961781, 35271311, 36931259, 20564478, 16205633, 24255178, 19470455, 28514442
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 473 Hs			1 246
+	Hs
		673560 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		673562 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		646657 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		673559 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		673571 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Xl
		223343 MPIP2_XENLA (1-469): 0: 569: 42.99		O57468_XENLA (4-243): 2.71e-143: 402: 66.12
+	Hs
		673546 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Rn
		89019 D4ADT2_RAT (1-473): 0: 546: 60.55		1433E_RAT (3-243): 4.39e-144: 405: 65.43
+	Mm
		823143 MPIP3_MOUSE (1-473): 0: 541: 59.24		1433E_MOUSE (3-243): 4.39e-144: 405: 65.43
+	Rn
		823141 MPIP2_RAT (112-468): 2.07e-143: 424: 38.80		1433E_RAT (3-243): 4.39e-144: 405: 65.43
+	Hs
		673381 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		673365 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		673452 MPIP2_HUMAN (121-468): 2.83e-140: 416: 40.11		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Mm
		673543 MPIP2_MOUSE (62-468): 5.73e-143: 423: 35.92		1433B_MOUSE (1-246): 5.56e-141: 396: 98.78
+	Hs
		673382 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		646655 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		646656 MPIP2_HUMAN (121-468): 2.83e-140: 416: 40.11		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		673380 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		673390 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		673366 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62