HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: BRD9 (Q9H8M2)
Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8)
Gene: BRD9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~Bromodomain, Bromodomain~DUF3512
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 801 Hs			1 597
+	Hs
		674345 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		BRD7_HUMAN (20-579): 1.78e-113: 354: 33.33
+	Hs
		1141312 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		BRD9_HUMAN (1-597): 1.24e-148: 443: 100.00
+	Hs
		674266 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		PHIP_HUMAN (95-507): 1.87e-47: 181: 15.84
+	Hs
		639666 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		TAF1_HUMAN (87-540): 7.76e-46: 176: 14.63
+	Hs
		674117 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		BRPF1_HUMAN (48-329): 5.04e-41: 162: 23.71
+	Hs
		674228 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		PB1_HUMAN (94-433): 5.09e-25: 112: 15.90
+	Hs
		1141184 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		ATAD2_HUMAN (22-526): 2.48e-57: 210: 14.26
+	Hs
		1141235 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		PHIP_HUMAN (95-507): 1.87e-47: 181: 15.84
+	Hs
		639734 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		TAF1_HUMAN (87-540): 7.76e-46: 176: 14.63
+	Hs
		1067742 EP300_HUMAN (31-183): 5.55e-39: 159: 30.72		BRD7_HUMAN (20-579): 1.78e-113: 354: 33.33
+	Hs
		1141197 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		PB1_HUMAN (94-433): 5.09e-25: 112: 15.90
+	Hs
		174572 TRI66_HUMAN (2-527): 1.16e-48: 188: 16.60		PHIP_HUMAN (95-507): 1.87e-47: 181: 15.84
+	Hs
		342364 BRPF3_HUMAN (204-764): 1.44e-35: 147: 15.59		BRD1_HUMAN (13-381): 2.56e-54: 201: 21.51
+	Sc
		763013 GCN5_YEAST (275-456): 3e-40: 155: 26.63		SPT7_YEAST (9-533): 1.81e-51: 193: 14.00
+	Hs
		1067228 EP300_HUMAN (31-183): 5.55e-39: 159: 30.72		EP300_HUMAN (50-330): 6.29e-48: 182: 19.87
+	Mm
		74238 EP300_MOUSE (202-448): 1.27e-40: 164: 24.71		F8VPR5_MOUSE (36-330): 2.85e-44: 172: 17.57
+	Sc
		777105 GCN5_YEAST (275-456): 3e-40: 155: 26.63		BDF1_YEAST (83-431): 3.28e-47: 177: 14.13
+	Hs
		1067564 EP300_HUMAN (31-183): 5.55e-39: 159: 30.72		CBP_HUMAN (36-330): 1.12e-43: 170: 17.57
+	Sc
		1042358 GCN5_YEAST (275-456): 3e-40: 155: 26.63		GCN5_YEAST (68-240): 1.85e-41: 157: 21.59
+	Hs
		1067567 EP300_HUMAN (31-183): 5.55e-39: 159: 30.72		KAT2B_HUMAN (114-229): 3.3e-23: 106: 27.27