HitPredict

Interactor 1: RPB2 (P30876)
DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48)
Gene: POLR2B

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16055720
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1174 Hs			1 1319
+	Sc
		440089 RPB2_YEAST (4-1173): 0: 1472: 58.05		TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42
+	Hs
		676997 RPB2_HUMAN (1-1174): 0: 1704: 100.00		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		125179 RPB2_HUMAN (1-1174): 0: 1704: 100.00		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		676969 RPB2_HUMAN (1-1174): 0: 1704: 100.00		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		677014 RPB2_HUMAN (1-1174): 0: 1704: 100.00		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82
+	Hs
		677041 RPB2_HUMAN (1-1174): 0: 1704: 100.00		HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83
+	Sc
		604605 RPA2_YEAST (31-1170): 0: 1105: 26.64		TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42
+	Sc
		440039 RPB2_YEAST (4-1173): 0: 1472: 58.05		RSP5_YEAST (388-669): 1.92e-30: 132: 14.41