HitPredict

Interactor 1: RPB2 (P30876)
DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48)
Gene: POLR2B

Interactor 2: RPAB3 (P52434)
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8)
Gene: POLR2H

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	9201987, 24981860, 35271311, 17643375
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001055 - RNA polymerase II activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005665 - RNA polymerase II, core complex GO:0006366 - transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1174 Hs			1 150
+	Sc
		439969 RPB2_YEAST (4-1173): 0: 1472: 58.05		RPAB3_YEAST (1-147): 2.38e-48: 154: 35.07
+	Sp
		968762 RPB2_SCHPO (6-1173): 0: 1481: 59.98		RPAB3_SCHPO (4-147): 5.15e-41: 135: 36.81
+	Hs
		854380 RPC2_HUMAN (18-1172): 0: 1360: 37.14		RPAB3_HUMAN (1-150): 1.61e-78: 231: 100.00
+	Sc
		593278 RPC2_YEAST (19-1171): 0: 1311: 36.09		RPAB3_YEAST (1-147): 2.38e-48: 154: 35.07
+	Hs
		854370 RPA2_HUMAN (36-1174): 0: 1199: 28.34		RPAB3_HUMAN (1-150): 1.61e-78: 231: 100.00
+	Sc
		593276 RPA2_YEAST (31-1170): 0: 1105: 26.64		RPAB3_YEAST (1-147): 2.38e-48: 154: 35.07