HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 870
+	Hs
		882215 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00
+	Hs
		882226 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00
+	Hs
		910159 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MACF1_HUMAN (505-867): 1.44e-74: 269: 13.79
+	Hs
		683813 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MACF1_HUMAN (505-867): 1.44e-74: 269: 13.79
+	Hs
		909464 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYST_HUMAN (457-866): 1.71e-67: 248: 12.07
+	Hs
		683282 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		DYST_HUMAN (457-866): 1.71e-67: 248: 12.07
+	Hs
		926949 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DYST_HUMAN (457-866): 1.71e-67: 248: 12.07
+	Hs
		909706 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DNMBP_HUMAN (7-559): 6.75e-29: 126: 15.27
+	Hs
		683469 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		DNMBP_HUMAN (7-559): 6.75e-29: 126: 15.27
+	Hs
		926964 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35
+	Hs
		297821 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		K0754_HUMAN (151-869): 1.64e-27: 122: 10.56
+	Hs
		297815 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		K0754_HUMAN (151-869): 1.64e-27: 122: 10.56
+	Hs
		927191 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DNMBP_HUMAN (7-559): 6.75e-29: 126: 15.27
+	Hs
		297824 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		K0754_HUMAN (151-869): 1.64e-27: 122: 10.56
+	Hs
		909712 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		OTOG_HUMAN (198-735): 1.5e-21: 103: 11.50
+	Hs
		683472 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		OTOG_HUMAN (198-735): 1.5e-21: 103: 11.50
+	Hs
		257595 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ANR17_HUMAN (67-718): 5.11e-09: 62.6: 9.52
+	Hs
		257572 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ANR17_HUMAN (67-718): 5.11e-09: 62.6: 9.52
+	Hs
		927045 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MDC1_HUMAN (48-774): 9.36e-10: 64.9: 9.16
+	Hs
		257597 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ANR17_HUMAN (67-718): 5.11e-09: 62.6: 9.52