HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: PKHA7 (Q6IQ23)
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)
Gene: PLEKHA7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	33961781, 35271311, 36931259, 24255178, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1121
+	Hs
		909680 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00
+	Hs
		910040 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		683724 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		876345 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		683225 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Mm
		926832 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		CNKR2_MOUSE (119-516): 8.05e-46: 181: 17.87
+	Hs
		125318 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39
+	Mm
		910223 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		CYH2_MOUSE (105-300): 1.44e-44: 168: 21.50
+	Hs
		125351 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39
+	Hs
		910027 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		683712 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Mm
		93264 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		E9PXB7_MOUSE (59-486): 2.89e-28: 125: 13.02
+	Mm
		910302 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		NED4L_MOUSE (59-486): 8.19e-27: 120: 12.02
+	Hs
		909930 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		NED4L_HUMAN (59-486): 2.54e-26: 118: 12.47
+	Hs
		683637 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		NED4L_HUMAN (59-486): 2.54e-26: 118: 12.47
+	Rn
		910358 1433E_RAT (3-243): 4.39e-144: 405: 65.43		NEDD4_RAT (11-97): 3.59e-19: 95.8: 25.93
+	Hs
		808077 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		683192 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Mm
		808343 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		NEDD4_MOUSE (14-322): 7.06e-14: 78.5: 11.64
+	Hs
		808081 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17