HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: KKCC1 (Q8N5S9)
Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)
Gene: CAMKK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32707033, 24255178
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 505
+	Hs
		909813 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Rn
		910354 1433E_RAT (3-243): 4.39e-144: 405: 65.43		KKCC1_RAT (1-505): 3.01e-153: 448: 93.66
+	Rn
		716562 1433B_RAT (1-246): 3.55e-141: 397: 98.37		KKCC1_RAT (1-505): 3.01e-153: 448: 93.66
+	Hs
		647107 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	At
		965360 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CIPKC_ARATH (103-501): 1.35e-132: 395: 23.47
+	At
		1280891 14337_ARATH (1-239): 1.25e-144: 406: 61.73		CIPKC_ARATH (103-501): 1.35e-132: 395: 23.47
+	Dm
		90534 1433E_DROME (3-245): 4.63e-144: 405: 64.90		E1JGN0_DROME (20-415): 1.71e-125: 395: 28.29
+	At
		788672 14333_ARATH (3-241): 4.44e-143: 402: 62.96		CIPKC_ARATH (103-501): 1.35e-132: 395: 23.47
+	Hs
		681770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKT1_HUMAN (60-474): 9.07e-130: 387: 21.33
+	Hs
		681776 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		AKT1_HUMAN (60-474): 9.07e-130: 387: 21.33
+	Hs
		904856 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Hs
		982274 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Rn
		905365 1433G_RAT (3-246): 1.91e-109: 317: 75.40		KKCC1_RAT (1-505): 3.01e-153: 448: 93.66
+	Rn
		935723 1433F_RAT (4-244): 8.67e-108: 312: 75.51		KKCC1_RAT (1-505): 3.01e-153: 448: 93.66
+	Hs
		684209 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Hs
		681766 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		AKT1_HUMAN (60-474): 9.07e-130: 387: 21.33
+	Hs
		684282 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		KKCC2_HUMAN (31-504): 7.59e-134: 401: 59.49
+	Hs
		681682 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		AKT1_HUMAN (60-474): 9.07e-130: 387: 21.33