HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: FOXO4 (P98177)
Forkhead box protein O4 (Fork head domain transcription factor AFX1)
Gene: FOXO4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	25416956, 36931259
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 505
+	Hs
		909442 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXO4_HUMAN (1-505): 4.98e-95: 299: 100.00
+	Hs
		926923 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FOXO4_HUMAN (1-505): 4.98e-95: 299: 100.00
+	Hs
		206808 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Hs
		683999 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		FOXO1_HUMAN (23-502): 1.08e-55: 199: 34.59
+	Hs
		206820 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Dm
		955013 1433E_DROME (2-247): 2.8e-144: 405: 58.07		FOXO_DROME (16-501): 3.68e-64: 221: 29.48
+	Hs
		909490 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXO1_HUMAN (23-502): 1.08e-55: 199: 34.59
+	Hs
		206822 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Hs
		926976 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FOXO1_HUMAN (23-502): 1.08e-55: 199: 34.59
+	Hs
		909439 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXK1_HUMAN (5-443): 4.01e-43: 164: 19.39
+	Hs
		909499 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FOXC1_HUMAN (70-237): 5.11e-40: 153: 27.93
+	Hs
		68643 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FOXO6_HUMAN (8-502): 2.05e-71: 237: 36.38
+	Hs
		926921 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FOXK1_HUMAN (5-443): 4.01e-43: 164: 19.39
+	Hs
		46292 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		A0A1X9RU27_HUMAN (8-502): 1.67e-65: 223: 32.36
+	Hs
		206799 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Hs
		68644 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		FOXO6_HUMAN (8-502): 2.05e-71: 237: 36.38
+	Hs
		46293 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		A0A1X9RU27_HUMAN (8-502): 1.67e-65: 223: 32.36
+	Hs
		206807 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Hs
		646840 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FOXO1_HUMAN (23-502): 1.08e-55: 199: 34.59
+	Hs
		646796 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FOXK1_HUMAN (5-443): 4.01e-43: 164: 19.39