Protein: KCTD3
BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45)

Gene: KCTD3
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q9Y597

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0051260 - protein homooligomerization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114759

CUL3
Cullin-3

7

20

Small-scale

0.962

High

1348700

SHKB1
SH3KBP1-binding protein 1

3

18

High-throughput

0.855

High

1258865

KCTD1
BTB/POZ domain-containing protein KCTD1

2

19

High-throughput

0.811

High

1402761

KCD15
BTB/POZ domain-containing protein KCTD15

2

19

High-throughput

0.811

High

684048

PTN3
Tyrosine-protein phosphatase non-receptor type 3

4

11

High-throughput

0.697

High

1398295

KCTD7
BTB/POZ domain-containing protein KCTD7

1

19

High-throughput

0.691

High

1431392

EPN3
Epsin-3

3

8

High-throughput

0.667

High

1412062

WDR83
WD repeat domain-containing protein 83

4

7

High-throughput

0.630

High

1419771

ASPC1
Tether containing UBX domain for GLUT4

2

2

High-throughput

0.628

High

1212249

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

20

High-throughput

0.611

High

643593

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

3

1

High-throughput

0.609

High

1116629

FHL3
Four and a half LIM domains protein 3

3

7

High-throughput

0.609

High

1491467

ARI1
E3 ubiquitin-protein ligase ARIH1

3

7

High-throughput

0.609

High

1358507

TPC14
Trafficking protein particle complex subunit 14

2

0

High-throughput

0.602

High

1150509

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

20

High-throughput

0.601

High

1418555

ACE2
Angiotensin-converting enzyme 2

2

1

Small-scale

0.584

High

931728

RD23B
UV excision repair protein RAD23 homolog B

2

6

High-throughput

0.574

High

957573

UBC12
NEDD8-conjugating enzyme Ubc12

2

8

High-throughput

0.574

High

1400453

TPPC9
Trafficking protein particle complex subunit 9

2

1

High-throughput

0.574

High

397322

ESR1
Estrogen receptor

2

9

High-throughput

0.571

High

1384317

SH3K1
SH3 domain-containing kinase-binding protein 1

2

16

High-throughput

0.571

High

679418

DNJB2
DnaJ homolog subfamily B member 2

2

10

High-throughput

0.558

High

1396880

SNX27
Sorting nexin-27

2

20

High-throughput

0.558

High

863047

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

8

High-throughput

0.536

High

931177

HSP72
Heat shock-related 70 kDa protein 2

1

15

High-throughput

0.536

High

1437694

PKHA5
Pleckstrin homology domain-containing family A member 5

2

16

Small-scale

0.533

High

1235051

PKHA7
Pleckstrin homology domain-containing family A member 7

2

18

High-throughput

0.521

High

882587

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

415964

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.494

High

162876

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.489

High

259191

DNJA2
DnaJ homolog subfamily A member 2

1

12

High-throughput

0.489

High

347440

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

766058

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.489

High

984040

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

High-throughput

0.489

High

1154972

NEDD8
Ubiquitin-like protein NEDD8

1

2

High-throughput

0.489

High

1215572

RNH2B
Ribonuclease H2 subunit B

1

1

High-throughput

0.489

High

1244467

DCNL2
DCN1-like protein 2

1

4

High-throughput

0.489

High

1272607

CSN6
COP9 signalosome complex subunit 6

1

4

High-throughput

0.489

High

1325125

MTURN
Maturin

1

4

High-throughput

0.489

High

1326176

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.489

High

1357072

FBLI1
Filamin-binding LIM protein 1

1

9

High-throughput

0.489

High

1370501

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.489

High

1371390

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

11

High-throughput

0.489

High

1382405

SPSB4
SPRY domain-containing SOCS box protein 4

1

9

High-throughput

0.489

High

1391985

DCNL1
DCN1-like protein 1

1

4

High-throughput

0.489

High

1407022

NPAS1
Neuronal PAS domain-containing protein 1

1

1

High-throughput

0.489

High

1435502

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.489

High

176905

DCLK1
Serine/threonine-protein kinase DCLK1

1

9

High-throughput

0.479

High

208766

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

8

High-throughput

0.479

High

269639

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

12

High-throughput

0.479

High

637987

NF1
Neurofibromin

1

8

High-throughput

0.479

High

648753

FGFR4
Fibroblast growth factor receptor 4

1

3

High-throughput

0.479

High

936498

AFAD
Afadin

1

20

High-throughput

0.479

High

955791

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

968055

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.479

High

1025613

CDK16
Cyclin-dependent kinase 16

1

7

High-throughput

0.479

High

1090209

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

13

High-throughput

0.479

High

1092523

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

12

High-throughput

0.479

High

1129998

MELK
Maternal embryonic leucine zipper kinase

1

6

High-throughput

0.479

High

1153800

NCOA1
Nuclear receptor coactivator 1

1

2

Small-scale

0.479

High

1219648

DEN4C
DENN domain-containing protein 4C

1

5

High-throughput

0.479

High

1248135

CRTC1
CREB-regulated transcription coactivator 1

1

9

High-throughput

0.479

High

1286568

PHLB2
Pleckstrin homology-like domain family B member 2

1

17

High-throughput

0.479

High

1293253

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

5

High-throughput

0.479

High

1401147

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.479

High

1419850

OSBL6
Oxysterol-binding protein-related protein 6

1

3

High-throughput

0.479

High

1433840

OSBL3
Oxysterol-binding protein-related protein 3

1

3

High-throughput

0.479

High

1434340

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.479

High

1448829

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

1

High-throughput

0.479

High

1453563

PD1L1
Programmed cell death 1 ligand 1

1

10

Small-scale

0.479

High

1454260

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

5

High-throughput

0.479

High

1454720

CING
Cingulin

1

6

High-throughput

0.479

High

1459764

LIMA1
LIM domain and actin-binding protein 1

1

12

High-throughput

0.479

High

1460950

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.479

High

1462709

BAIP2
BAR/IMD domain-containing adapter protein 2

1

7

High-throughput

0.479

High

1462724

GAB2
GRB2-associated-binding protein 2

1

9

High-throughput

0.479

High

344584

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

2

High-throughput

0.464

High

1409811

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

173610

XPO1
Exportin-1

1

14

High-throughput

0.437

High

230598

KIF1C
Kinesin-like protein KIF1C

1

14

High-throughput

0.437

High

245300

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

7

High-throughput

0.437

High

246201

KIF1B
Kinesin-like protein KIF1B

1

14

High-throughput

0.437

High

252209

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.437

High

281464

GGYF1
GRB10-interacting GYF protein 1

1

3

High-throughput

0.437

High

354816

PAK4
Serine/threonine-protein kinase PAK 4

1

3

High-throughput

0.437

High

590135

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696974

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

719052

WEE1
Wee1-like protein kinase

1

8

High-throughput

0.437

High

719286

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.437

High

719392

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.437

High

769616

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

877053

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.437

High

905341

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.437

High

941107

HDAC4
Histone deacetylase 4

1

3

High-throughput

0.437

High

942981

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

12

High-throughput

0.437

High

1065794

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

9

High-throughput

0.437

High

1108322

SQSTM
Sequestosome-1

1

2

High-throughput

0.437

High

1134095

ZN638
Zinc finger protein 638

1

4

High-throughput

0.437

High

1152069

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

12

High-throughput

0.437

High

1198363

CRTC2
CREB-regulated transcription coactivator 2

1

7

High-throughput

0.437

High

1216114

SPD2A
SH3 and PX domain-containing protein 2A

1

12

High-throughput

0.437

High

1229799

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

1229915

AN34A
Ankyrin repeat domain-containing protein 34A

1

17

High-throughput

0.437

High

1238324

REEP3
Receptor expression-enhancing protein 3

1

1

High-throughput

0.437

High

1242710

KLC3
Kinesin light chain 3

1

3

High-throughput

0.437

High

1245779

LARP1
La-related protein 1

1

5

High-throughput

0.437

High

1248125

CRTC3
CREB-regulated transcription coactivator 3

1

6

High-throughput

0.437

High

1251482

GGYF2
GRB10-interacting GYF protein 2

1

15

High-throughput

0.437

High

1256812

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

15

High-throughput

0.437

High

1257061

SYDE1
Rho GTPase-activating protein SYDE1

1

14

High-throughput

0.437

High

1272900

RFIP2
Rab11 family-interacting protein 2

1

15

High-throughput

0.437

High

1277723

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.437

High

1287263

TBCD1
TBC1 domain family member 1

1

1

High-throughput

0.437

High

1309273

KSR1
Kinase suppressor of Ras 1

1

2

High-throughput

0.437

High

1309511

CEP97
Centrosomal protein of 97 kDa

1

15

Small-scale

0.437

High

1316206

DCP1B
mRNA-decapping enzyme 1B

1

10

High-throughput

0.437

High

1322688

RPTOR
Regulatory-associated protein of mTOR

1

8

High-throughput

0.437

High

1325151

MILK1
MICAL-like protein 1

1

19

High-throughput

0.437

High

1338132

NAV1
Neuron navigator 1

1

10

High-throughput

0.437

High

1349489

F110B
Protein FAM110B

1

2

High-throughput

0.437

High

1352628

DEN1A
DENN domain-containing protein 1A

1

6

High-throughput

0.437

High

1352646

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

16

High-throughput

0.437

High

1356786

HDAC7
Histone deacetylase 7

1

3

High-throughput

0.437

High

1357451

DEP1B
DEP domain-containing protein 1B

1

4

High-throughput

0.437

High

1359471

LMO7
LIM domain only protein 7

1

10

High-throughput

0.437

High

1360425

SRS12
Serine/arginine-rich splicing factor 12

1

6

High-throughput

0.437

High

1367689

ESR2
Estrogen receptor beta

1

8

High-throughput

0.437

High

1390935

SCRN2
Secernin-2

1

1

High-throughput

0.437

High

1403623

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.437

High

1410273

F110A
Protein FAM110A

1

2

High-throughput

0.437

High

1417116

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

10

High-throughput

0.437

High

1438859

TANC2
Protein TANC2

1

9

High-throughput

0.437

High

1446500

DCP1A
mRNA-decapping enzyme 1A

1

4

High-throughput

0.437

High

1447288

KI13B
Kinesin-like protein KIF13B

1

11

High-throughput

0.437

High

1460602

NGAP
Ras GTPase-activating protein nGAP

1

8

High-throughput

0.437

High

1462526

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

7

High-throughput

0.437

High

1462754

HDAC5
Histone deacetylase 5

1

3

High-throughput

0.437

High

1491257

STA13
StAR-related lipid transfer protein 13

1

12

High-throughput

0.437

High

71071

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

20

High-throughput

0.407

High

730398

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.407

High

931628

RD23A
UV excision repair protein RAD23 homolog A

1

6

High-throughput

0.407

High

958742

CSN2
COP9 signalosome complex subunit 2

1

8

High-throughput

0.407

High

1063909

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.407

High

1094454

CSN1
COP9 signalosome complex subunit 1

1

7

High-throughput

0.407

High

1211050

CE170
Centrosomal protein of 170 kDa

1

11

High-throughput

0.407

High

1352150

EOLA1
Protein EOLA1

1

1

High-throughput

0.407

High

1401913

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.407

High

1326560

CARME
Carnosine N-methyltransferase

3

0

High-throughput

0.347

High

1286684

TPC6B
Trafficking protein particle complex subunit 6B

2

0

High-throughput

0.328

High

163199

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.249

Low

339124

NADK
NAD kinase

1

0

High-throughput

0.249

Low

1216041

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.249

Low

1383958

DACT3
Dapper homolog 3

1

0

High-throughput

0.249

Low

1390432

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.249

Low

1402235

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.249

Low

1410861

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

1412899

RTKN
Rhotekin

1

0

High-throughput

0.249

Low

1419474

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.249

Low

1429339

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.249

Low

1451989

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.249

Low

1452558

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1461595

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.249

Low

1461676

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.249

Low

1491255

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025