HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17361185, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003334 - keratinocyte development GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045296 - cadherin binding GO:0061436 - establishment of skin barrier and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 4684
+	Hs
		927068 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		PLEC_HUMAN (1-4684): 0: 1783: 100.00
+	Mm
		926889 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		PLEC_MOUSE (1-4684): 0: 1747: 93.29
+	Hs
		646909 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		PLEC_HUMAN (1-4684): 0: 1783: 100.00
+	Hs
		926965 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ACTN3_HUMAN (166-893): 2.36e-146: 484: 25.79
+	Hs
		506805 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		SPTB1_HUMAN (151-2274): 6.68e-124: 442: 17.12
+	Hs
		683978 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51
+	Hs
		684396 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92
+	Mm
		926814 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		Q68FG2_MOUSE (1390-3166): 7.42e-23: 111: 11.85
+	Hs
		646760 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		EPIPL_HUMAN (3039-3941): 6.03e-42: 174: 27.75
+	Mm
		93548 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		DESP_MOUSE (351-883): 3.06e-11: 72.7: 8.07
+	Hs
		909464 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51
+	Hs
		910159 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92
+	Mm
		926806 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		SPTB2_MOUSE (1531-3013): 1.72e-17: 93.1: 9.54
+	Hs
		926931 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53
+	Hs
		926949 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51
+	Hs
		927659 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92
+	Hs
		551660 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21
+	Hs
		646893 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		GOGB1_HUMAN (2666-3718): 4.33e-13: 78.9: 11.65
+	Hs
		646817 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51
+	Hs
		647380 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92