HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: TNK1 (Q13470)
Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
Gene: TNK1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	25852190, 15778465, 36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, cross-linking study, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 666
+	Hs
		909526 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		TNK1_HUMAN (1-666): 0: 538: 100.00
+	Hs
		337367 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ABL1_HUMAN (22-643): 2.23e-124: 397: 21.38
+	Hs
		383641 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ERBB2_HUMAN (65-631): 7.95e-122: 393: 22.82
+	Hs
		337416 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ABL1_HUMAN (22-643): 2.23e-124: 397: 21.38
+	Hs
		383724 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ERBB2_HUMAN (65-631): 7.95e-122: 393: 22.82
+	At
		965327 14332_ARATH (3-248): 2.23e-144: 405: 58.47		PBS1_ARATH (36-471): 3.55e-129: 390: 17.94
+	Hs
		411616 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		LCK_HUMAN (91-392): 1.46e-113: 352: 30.46
+	Hs
		337420 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ABL1_HUMAN (22-643): 2.23e-124: 397: 21.38
+	Hs
		383732 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ERBB2_HUMAN (65-631): 7.95e-122: 393: 22.82
+	At
		788521 14333_ARATH (3-247): 2.63e-144: 405: 58.30		PBL9_ARATH (59-404): 2.54e-121: 369: 21.96
+	Hs
		411661 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		LCK_HUMAN (91-392): 1.46e-113: 352: 30.46
+	Hs
		411666 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		LCK_HUMAN (91-392): 1.46e-113: 352: 30.46
+	Hs
		684051 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ERBB4_HUMAN (89-373): 2.84e-46: 179: 36.68
+	Hs
		338009 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		684033 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		FAK2_HUMAN (92-373): 3.64e-45: 175: 36.88
+	Hs
		909589 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ERBB4_HUMAN (89-373): 2.84e-46: 179: 36.68
+	Hs
		338232 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		909560 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FAK2_HUMAN (92-373): 3.64e-45: 175: 36.88
+	Hs
		338257 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		926964 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ACK1_HUMAN (391-664): 6.16e-22: 103: 20.79