Protein: SHKB1
SH3KBP1-binding protein 1 (SETA-binding protein 1)

Gene: SHKB1, SHKBP1
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q8TBC3

Gene Ontology (top 5):
GO:0005764 - lysosome
GO:0042802 - identical protein binding
GO:0045742 - positive regulation of epidermal growth factor receptor signaling pathway
GO:0051260 - protein homooligomerization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113774

CUL3
Cullin-3

8

20

Small-scale

0.861

High

1348700

KCTD3
BTB/POZ domain-containing protein KCTD3

3

18

High-throughput

0.855

High

1348667

SHKB1
SH3KBP1-binding protein 1

2

16

High-throughput

0.783

High

1199610

KLH22
Kelch-like protein 22

1

5

High-throughput

0.691

High

1348679

KCTD7
BTB/POZ domain-containing protein KCTD7

1

18

High-throughput

0.691

High

1348683

WDR83
WD repeat domain-containing protein 83

4

7

High-throughput

0.691

High

639273

TNAP3
Tumor necrosis factor alpha-induced protein 3

3

8

High-throughput

0.662

High

966650

1433G
14-3-3 protein gamma

4

20

High-throughput

0.638

High

684017

PTN3
Tyrosine-protein phosphatase non-receptor type 3

4

20

High-throughput

0.636

High

1348675

SH3K1
SH3 domain-containing kinase-binding protein 1

4

20

Small-scale

0.628

High

643524

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

3

1

High-throughput

0.609

High

1116546

FHL3
Four and a half LIM domains protein 3

3

9

High-throughput

0.609

High

1348688

EPN3
Epsin-3

3

12

High-throughput

0.609

High

1348699

ARI1
E3 ubiquitin-protein ligase ARIH1

3

7

High-throughput

0.609

High

730076

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.604

High

1049589

1433F
14-3-3 protein eta

3

20

High-throughput

0.604

High

1348687

ASPC1
Tether containing UBX domain for GLUT4

3

2

High-throughput

0.604

High

1348696

FEM1B
Protein fem-1 homolog B

3

16

High-throughput

0.604

High

957446

UBC12
NEDD8-conjugating enzyme Ubc12

2

9

High-throughput

0.574

High

1046391

UBXN1
UBX domain-containing protein 1

2

11

High-throughput

0.558

High

1212228

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

20

High-throughput

0.558

High

1348678

SNX27
Sorting nexin-27

2

20

High-throughput

0.558

High

1150456

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

20

High-throughput

0.549

High

540578

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.536

High

1348680

VPS35
Vacuolar protein sorting-associated protein 35

1

1

High-throughput

0.536

High

987789

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.534

High

1348686

ACE2
Angiotensin-converting enzyme 2

2

1

Small-scale

0.533

High

396566

ESR1
Estrogen receptor

2

9

High-throughput

0.521

High

162848

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.489

High

259001

DNJA2
DnaJ homolog subfamily A member 2

1

11

High-throughput

0.489

High

295612

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.489

High

334218

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

5

High-throughput

0.489

High

347194

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.489

High

350723

NOE2
Noelin-2

1

2

High-throughput

0.489

High

359845

DYR
Dihydrofolate reductase

1

1

High-throughput

0.489

High

366426

FA12
Coagulation factor XII

1

2

High-throughput

0.489

High

708859

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

20

High-throughput

0.489

High

765728

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.489

High

783629

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

8

High-throughput

0.489

High

983898

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

High-throughput

0.489

High

1122291

SCRIB
Protein scribble homolog

1

20

High-throughput

0.489

High

1154874

NEDD8
Ubiquitin-like protein NEDD8

1

2

High-throughput

0.489

High

1177036

INF2
Inverted formin-2

1

4

High-throughput

0.489

High

1272493

CSN6
COP9 signalosome complex subunit 6

1

4

High-throughput

0.489

High

1325108

MTURN
Maturin

1

4

High-throughput

0.489

High

1325807

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1325999

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.489

High

1348670

FBLI1
Filamin-binding LIM protein 1

1

10

High-throughput

0.489

High

1348673

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.489

High

1348674

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.489

High

1348676

DCNL1
DCN1-like protein 1

1

4

High-throughput

0.489

High

1348697

AT7L1
Ataxin-7-like protein 1

1

8

High-throughput

0.489

High

508315

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.457

High

404251

GCR
Glucocorticoid receptor

1

8

Small-scale

0.439

High

1109335

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.439

High

173111

XPO1
Exportin-1

1

18

High-throughput

0.437

High

177271

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

10

High-throughput

0.437

High

581183

RAC2
Ras-related C3 botulinum toxin substrate 2

1

9

High-throughput

0.437

High

648598

FGFR4
Fibroblast growth factor receptor 4

1

9

High-throughput

0.437

High

730782

1433S
14-3-3 protein sigma

1

20

High-throughput

0.437

High

904951

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.437

High

955399

CDC42
Cell division control protein 42 homolog

1

10

High-throughput

0.437

High

967867

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.437

High

971806

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.437

High

988543

RAC1
Ras-related C3 botulinum toxin substrate 1

1

10

High-throughput

0.437

High

1107948

SQSTM
Sequestosome-1

1

2

High-throughput

0.437

High

1164371

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

1

High-throughput

0.437

High

1165476

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

7

High-throughput

0.437

High

1252140

SYNE3
Nesprin-3

1

19

High-throughput

0.437

High

1280881

CNTRL
Centriolin

1

19

High-throughput

0.437

High

1309461

CEP97
Centrosomal protein of 97 kDa

1

18

Small-scale

0.437

High

1348671

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

8

High-throughput

0.437

High

1348672

ESR2
Estrogen receptor beta

1

8

High-throughput

0.437

High

1348681

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.437

High

1348682

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.437

High

1348685

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

9

High-throughput

0.437

High

1348689

RHOJ
Rho-related GTP-binding protein RhoJ

1

12

High-throughput

0.437

High

1348690

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1348691

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.437

High

1348692

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

Small-scale

0.437

High

1348698

NINL
Ninein-like protein

1

13

High-throughput

0.437

High

1036627

CO7A1
Collagen alpha-1(VII) chain

1

10

High-throughput

0.417

High

71062

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

20

High-throughput

0.407

High

222155

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.407

High

931567

RD23A
UV excision repair protein RAD23 homolog A

1

6

High-throughput

0.407

High

958675

CSN2
COP9 signalosome complex subunit 2

1

10

High-throughput

0.407

High

1063822

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.407

High

1094381

CSN1
COP9 signalosome complex subunit 1

1

8

High-throughput

0.407

High

1210920

CE170
Centrosomal protein of 170 kDa

1

16

High-throughput

0.407

High

1211580

C2D1B
Coiled-coil and C2 domain-containing protein 1B

1

8

High-throughput

0.407

High

1227106

A16L1
Autophagy-related protein 16-1

1

16

High-throughput

0.407

High

1253635

PKHG7
Pleckstrin homology domain-containing family G member 7

1

18

High-throughput

0.407

High

1258514

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.407

High

1348669

EOLA1
Protein EOLA1

1

1

High-throughput

0.407

High

1348695

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

4

High-throughput

0.407

High

1348677

TET5A
Terminal nucleotidyltransferase 5A

2

0

High-throughput

0.328

High

1348693

GLTP
Glycolipid transfer protein

2

0

High-throughput

0.328

High

215151

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

0

High-throughput

0.316

High

1348684

LXN
Latexin

2

0

High-throughput

0.316

High

191372

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.279

Low

239147

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

261527

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

296806

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

570936

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.279

Low

1009802

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.279

Low

1064587

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.279

Low

1207240

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1311501

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.279

Low

1348668

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.279

Low

1348701

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.279

Low

909290

CCNG1
Cyclin-G1

1

0

High-throughput

0.251

Low

629969

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

1252343

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.249

Low

1348694

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.249

Low

213205

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

516925

CB27B
Putative uncharacterized protein CDRT15P3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025