HitPredict

Interactor 1: CCR1 (P32246)
C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
Gene: CCR1

Interactor 2: CCL14 (Q16627)
C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)]
Gene: CCL14

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	9687537, 12381680, 9346309, 15905581, 9548457
Identification Methods	biochemical, experimental interaction detection, competition binding, fluorescence technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006874 - intracellular calcium ion homeostasis GO:0006954 - inflammatory response GO:0070098 - chemokine-mediated signaling pathway GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 93
+	Hs
		561728 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CL3L1_HUMAN (1-93): 7.63e-37: 121: 45.16
+	Hs
		526560 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL4_HUMAN (1-93): 1.17e-35: 118: 43.01
+	Hs
		486230 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL3_HUMAN (1-93): 4.88e-34: 113: 45.16
+	Mm
		500591 CCR3_MOUSE (9-355): 1.75e-86: 266: 64.55		CCL3_MOUSE (1-93): 7.01e-36: 118: 44.09
+	Hs
		686635 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL8_HUMAN (17-92): 6.18e-30: 103: 35.07
+	Hs
		686636 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL7_HUMAN (18-92): 2.68e-29: 101: 30.26
+	Hs
		686626 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL23_HUMAN (1-93): 5.76e-28: 99.3: 35.40
+	Hs
		686668 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL15_HUMAN (1-91): 5.63e-28: 99.3: 32.73
+	Hs
		528201 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL2_HUMAN (17-92): 2.14e-27: 97.4: 28.57
+	Mm
		534669 CCR3_MOUSE (9-355): 1.75e-86: 266: 64.55		CCL4_MOUSE (18-93): 3.94e-31: 106: 46.05
+	Hs
		528244 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL5_HUMAN (1-93): 8.62e-27: 95.4: 36.56
+	Hs
		607526 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL1_HUMAN (1-91): 2.03e-25: 92.4: 31.87
+	Hs
		180158 CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00		CCL16_HUMAN (1-89): 6.8e-24: 89.3: 39.56
+	Mm
		486212 CCR8_MOUSE (7-335): 4.97e-92: 280: 40.06		CCL1_MOUSE (1-90): 3.6e-22: 83.9: 24.18
+	Hs
		849723 CCR8_HUMAN (12-337): 2.77e-85: 263: 42.30		CCL18_HUMAN (1-93): 3.19e-28: 99.3: 40.86
+	Hs
		849725 CCR8_HUMAN (12-337): 2.77e-85: 263: 42.30		CCL17_HUMAN (5-91): 1.29e-26: 95.1: 30.34
+	Hs
		607528 CCR8_HUMAN (12-337): 2.77e-85: 263: 42.30		CCL1_HUMAN (1-91): 2.03e-25: 92.4: 31.87
+	Hs
		180162 CCR8_HUMAN (12-337): 2.77e-85: 263: 42.30		CCL16_HUMAN (1-89): 6.8e-24: 89.3: 39.56
+	Hs
		134312 ACKR4_HUMAN (8-343): 5.14e-84: 260: 32.16		CCL21_HUMAN (32-92): 3.43e-18: 75: 27.69
+	Hs
		179471 ACKR4_HUMAN (8-343): 5.14e-84: 260: 32.16		CCL25_HUMAN (5-91): 1.26e-14: 66.2: 23.66