HitPredict

Interactor 1: SL9A3 (P48764)
Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)
Gene: SLC9A3

Interactor 2: CHP1 (Q99653)
Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22)
Gene: CHP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	12576672, unassigned3795, 35613257
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, molecular sieving, 3D electron microscopy
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0015385 - sodium:proton antiporter activity GO:0051453 - regulation of intracellular pH GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 834 Hs			1 195
+	Hs
		225743 SL9A3_HUMAN (1-834): 0: 887: 100.00		CHP2_HUMAN (1-194): 2.72e-48: 157: 61.03
+	Rn
		686670 SL9A3_RAT (1-834): 0: 855: 89.01		CHP1_RAT (1-195): 2.54e-50: 162: 98.97
+	Rn
		686671 SL9A3_RAT (1-834): 0: 855: 89.01		CHP2_RAT (1-194): 3.1e-45: 149: 61.54
+	Rn
		877641 SL9A2_RAT (15-777): 0: 691: 40.47		CHP1_RAT (1-195): 2.54e-50: 162: 98.97
+	Rn
		877642 SL9A2_RAT (15-777): 0: 691: 40.47		CHP2_RAT (1-194): 3.1e-45: 149: 61.54
+	Hs
		1406244 SL9A2_HUMAN (15-777): 0: 668: 39.85		CHP1_HUMAN (1-195): 1.74e-50: 163: 100.00
+	Hs
		225752 SL9A2_HUMAN (15-777): 0: 668: 39.85		CHP2_HUMAN (1-194): 2.72e-48: 157: 61.03
+	Hs
		624666 SL9A1_HUMAN (17-779): 0: 587: 38.80		CHP1_HUMAN (1-195): 1.74e-50: 163: 100.00
+	Hs
		225742 SL9A1_HUMAN (17-779): 0: 587: 38.80		CHP2_HUMAN (1-194): 2.72e-48: 157: 61.03
+	Hs
		624660 SL9A1_HUMAN (17-779): 0: 587: 38.80		CHP3_HUMAN (1-195): 1.09e-46: 154: 33.33
+	Hs
		1133802 SL9A5_HUMAN (42-698): 0: 563: 60.61		CHP1_HUMAN (1-195): 1.74e-50: 163: 100.00
+	Hs
		225746 SL9A5_HUMAN (42-698): 0: 563: 60.61		CHP2_HUMAN (1-194): 2.72e-48: 157: 61.03
+	Hs
		1230839 SL9A4_HUMAN (39-682): 0: 554: 39.97		CHP1_HUMAN (1-195): 1.74e-50: 163: 100.00
+	Rn
		956641 SL9A5_RAT (27-700): 0: 554: 59.27		CHP1_RAT (1-195): 2.54e-50: 162: 98.97
+	Rn
		686667 SL9A1_RAT (30-779): 0: 553: 38.75		CHP1_RAT (1-195): 2.54e-50: 162: 98.97
+	Hs
		225748 SL9A4_HUMAN (39-682): 0: 554: 39.97		CHP2_HUMAN (1-194): 2.72e-48: 157: 61.03
+	Rn
		686673 SL9A4_RAT (39-682): 0: 542: 39.20		CHP1_RAT (1-195): 2.54e-50: 162: 98.97
+	Rn
		1283499 SL9A5_RAT (27-700): 0: 554: 59.27		CHP2_RAT (1-194): 3.1e-45: 149: 61.54
+	Rn
		686668 SL9A1_RAT (30-779): 0: 553: 38.75		CHP2_RAT (1-194): 3.1e-45: 149: 61.54
+	Rn
		686674 SL9A4_RAT (39-682): 0: 542: 39.20		CHP2_RAT (1-194): 3.1e-45: 149: 61.54