Protein: SI1L2
Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)

Gene: SI1L2, SIPA1L2
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q9P2F8

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0051056 - regulation of small GTPase mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

683781

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.722

High

640651

DDX6
Probable ATP-dependent RNA helicase DDX6

5

3

High-throughput

0.720

High

905209

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

927611

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.699

High

982577

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

196519

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

9

High-throughput

0.691

High

230281

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

11

High-throughput

0.691

High

1291409

SIPA1
Signal-induced proliferation-associated protein 1

1

8

High-throughput

0.691

High

1350318

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

4

High-throughput

0.691

High

647347

1433T
14-3-3 protein theta

3

20

High-throughput

0.667

High

910116

1433E
14-3-3 protein epsilon

2

11

High-throughput

0.635

High

1310197

LZTS2
Leucine zipper putative tumor suppressor 2

4

19

High-throughput

0.633

High

1344042

PDLI7
PDZ and LIM domain protein 7

1

7

High-throughput

0.618

High

350638

RASK
GTPase KRas

1

16

High-throughput

0.618

High

1172074

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

1350320

AP3M1
AP-3 complex subunit mu-1

3

1

High-throughput

0.616

High

1326874

NXF2
Nuclear RNA export factor 2

2

0

High-throughput

0.602

High

612122

PROZ
Vitamin K-dependent protein Z

2

1

High-throughput

0.574

High

1328216

TSYL1
Testis-specific Y-encoded-like protein 1

2

1

High-throughput

0.574

High

1350321

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

11

High-throughput

0.574

High

876525

AFAD
Afadin

1

17

High-throughput

0.553

High

916041

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.553

High

1129608

SMAG2
Protein Smaug homolog 2

1

1

High-throughput

0.553

High

1256912

PARD3
Partitioning defective 3 homolog

1

15

High-throughput

0.553

High

230555

LZTS3
Leucine zipper putative tumor suppressor 3

1

14

High-throughput

0.536

High

535950

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

729188

K22E
Keratin, type II cytoskeletal 2 epidermal

1

3

High-throughput

0.536

High

806719

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.536

High

1283601

TRI52
E3 ubiquitin-protein ligase TRIM52

1

2

High-throughput

0.536

High

1316220

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

1327795

RGAP1
Rac GTPase-activating protein 1

1

2

High-throughput

0.536

High

1332714

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1350316

LZTS1
Leucine zipper putative tumor suppressor 1

1

19

High-throughput

0.536

High

325923

LATS1
Serine/threonine-protein kinase LATS1

2

7

High-throughput

0.533

High

1145965

CP135
Centrosomal protein of 135 kDa

2

4

High-throughput

0.533

High

1152548

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

2

2

High-throughput

0.533

High

1124642

ODFP2
Outer dense fiber protein 2

2

5

High-throughput

0.521

High

1269814

ESR2
Estrogen receptor beta

2

17

High-throughput

0.521

High

1219605

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.513

High

1350323

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

63184

U119B
Protein unc-119 homolog B

1

1

High-throughput

0.489

High

165788

N4BP3
NEDD4-binding protein 3

1

12

High-throughput

0.489

High

1034207

U119A
Protein unc-119 homolog A

1

1

High-throughput

0.489

High

1138232

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

5

High-throughput

0.489

High

256121

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

387648

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

408945

K1C18
Keratin, type I cytoskeletal 18

1

1

High-throughput

0.479

High

409261

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

430363

PROF1
Profilin-1

1

1

High-throughput

0.479

High

443856

VIME
Vimentin

1

10

High-throughput

0.479

High

535590

GFAP
Glial fibrillary acidic protein

1

10

High-throughput

0.479

High

567311

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

575865

VINC
Vinculin

1

3

High-throughput

0.479

High

684372

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

717391

CTNB1
Catenin beta-1

1

5

High-throughput

0.479

High

780243

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

818551

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.479

High

835550

GSK3A
Glycogen synthase kinase-3 alpha

1

10

High-throughput

0.479

High

836050

GSK3B
Glycogen synthase kinase-3 beta

1

10

High-throughput

0.479

High

892082

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.479

High

896838

ARP3
Actin-related protein 3

1

6

High-throughput

0.479

High

967994

PO5F1
POU domain, class 5, transcription factor 1

1

4

High-throughput

0.479

High

1042719

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1044224

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.479

High

1074426

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

1080805

ZYX
Zyxin

1

4

High-throughput

0.479

High

1119081

AMOT
Angiomotin

1

7

High-throughput

0.479

High

1147671

FTM
Protein fantom

1

8

High-throughput

0.479

High

1165008

SAS6
Spindle assembly abnormal protein 6 homolog

1

4

High-throughput

0.479

High

1168724

SYNE3
Nesprin-3

1

6

High-throughput

0.479

High

1307333

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

3

High-throughput

0.479

High

1350312

HOOK1
Protein Hook homolog 1

1

5

High-throughput

0.479

High

1034421

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.470

High

1218657

DEN6A
Protein DENND6A

1

0

High-throughput

0.458

High

1350317

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

1284325

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

2

High-throughput

0.445

High

1302345

CK5P2
CDK5 regulatory subunit-associated protein 2

1

6

High-throughput

0.445

High

1283804

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.438

High

164495

TRI66
Tripartite motif-containing protein 66

1

5

High-throughput

0.437

High

178833

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

279744

FLOT1
Flotillin-1

1

2

High-throughput

0.437

High

411880

LCK
Tyrosine-protein kinase Lck

1

2

High-throughput

0.437

High

823506

PAXI
Paxillin

1

4

High-throughput

0.437

High

840596

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.437

High

1081161

CCDC6
Coiled-coil domain-containing protein 6

1

6

High-throughput

0.437

High

1084221

OCLN
Occludin

1

4

High-throughput

0.437

High

1101350

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1148253

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.437

High

1172778

CE128
Centrosomal protein of 128 kDa

1

6

High-throughput

0.437

High

1183783

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.437

High

1198402

PATL1
Protein PAT1 homolog 1

1

1

High-throughput

0.437

High

1232704

FBXW8
F-box/WD repeat-containing protein 8

1

8

High-throughput

0.437

High

1233475

NIN
Ninein

1

11

High-throughput

0.437

High

1239450

F184A
Protein FAM184A

1

3

High-throughput

0.437

High

1291727

BICD1
Protein bicaudal D homolog 1

1

7

High-throughput

0.437

High

1311555

PCGF1
Polycomb group RING finger protein 1

1

3

High-throughput

0.437

High

1313543

CP250
Centrosome-associated protein CEP250

1

4

High-throughput

0.437

High

1334430

NANOG
Homeobox protein NANOG

1

6

High-throughput

0.437

High

1344956

LATS2
Serine/threonine-protein kinase LATS2

1

10

High-throughput

0.437

High

1350311

ANFY1
Rabankyrin-5

1

3

High-throughput

0.437

High

1350313

ANC2
Anaphase-promoting complex subunit 2

1

5

High-throughput

0.437

High

1350314

FBW1B
F-box/WD repeat-containing protein 11

1

6

High-throughput

0.437

High

1350319

NINL
Ninein-like protein

1

10

High-throughput

0.437

High

70215

B2CML4
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3DE

1

2

High-throughput

0.407

High

533092

PRG2
Bone marrow proteoglycan

3

0

High-throughput

0.347

High

1132268

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

1350315

CELA1
Chymotrypsin-like elastase family member 1

2

0

High-throughput

0.328

High

1237653

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

0

High-throughput

0.316

High

953184

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

1101786

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1224015

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1239210

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

1292825

SYMM
Methionine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1345341

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low

1350322

SNX5
Sorting nexin-5

1

0

High-throughput

0.279

Low

217281

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.251

Low

602881

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.251

Low

166328

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

887214

DJB13
DnaJ homolog subfamily B member 13

1

0

High-throughput

0.249

Low

1200714

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

1292775

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024