HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	36931259, 15161933, unassigned3799
Identification Methods	proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1192
+	Hs
		971640 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		WWC2_HUMAN (1-1192): 0: 1073: 100.00
+	Hs
		971757 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		KIBRA_HUMAN (1-1192): 0: 925: 48.79
+	Hs
		691223 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		KIBRA_HUMAN (1-1192): 0: 925: 48.79
+	Hs
		691419 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		WWP1_HUMAN (6-143): 3.65e-36: 150: 22.67
+	Hs
		131896 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		WWP2_HUMAN (3-143): 7.2e-31: 133: 23.84
+	Hs
		691353 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		MAGI1_HUMAN (1-97): 8.81e-33: 140: 38.53
+	Hs
		691335 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		ITCH_HUMAN (10-143): 1.83e-32: 138: 24.83
+	Hs
		131746 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		WWP2_HUMAN (3-143): 7.2e-31: 133: 23.84
+	Hs
		971994 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		SAV1_HUMAN (4-88): 4.56e-27: 116: 38.82
+	Mm
		861863 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		NEDD4_MOUSE (54-169): 6.58e-20: 98.1: 19.33
+	Hs
		861551 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		NEDD4_HUMAN (4-295): 3.75e-18: 92.7: 14.93
+	Hs
		971900 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		NED4L_HUMAN (7-163): 9.72e-18: 91.2: 14.65
+	Mm
		97731 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		E9PXB7_MOUSE (59-163): 3.54e-17: 89.2: 15.28
+	Mm
		972278 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		NED4L_MOUSE (59-163): 4.86e-17: 88.8: 15.28
+	Hs
		690817 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		NEDD4_HUMAN (4-295): 3.75e-18: 92.7: 14.93
+	Hs
		691348 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		NED4L_HUMAN (7-163): 9.72e-18: 91.2: 14.65
+	Mm
		97733 1433T_MOUSE (1-245): 2.97e-141: 397: 99.59		E9PXB7_MOUSE (59-163): 3.54e-17: 89.2: 15.28
+	Hs
		691452 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		SMUF1_HUMAN (40-193): 2.99e-14: 79.6: 16.58
+	Rn
		972334 1433E_RAT (2-243): 1.32e-144: 406: 63.53		NEDD4_RAT (1-278): 1.01e-09: 65: 13.33
+	Rn
		996640 1433T_RAT (1-245): 2.97e-141: 397: 99.59		NEDD4_RAT (1-278): 1.01e-09: 65: 13.33