Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.914

The method score is based on:

Property Details
Experiments 28065597, 28205554, 19567782, 18797457, 19525919
Identification Methods two hybrid, fluorescent resonance energy transfer, affinity chromatography technology, enzymatic study, x-ray crystallography
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EphA2_TM~PK_Tyr_Ser-Thr, Ephrin_lbd~Ephrin_lbd, Ephrin_lbd~fn3, fn3~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1, SAM_1~SAM_1
Common GO terms GO:0001501 - skeletal system development
GO:0001525 - angiogenesis
GO:0001570 - vasculogenesis
GO:0001618 - virus receptor activity
GO:0001649 - osteoblast differentiation
and 53 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 976
Hs

1 976
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025