Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2
Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.45 | 1.00 | 0.675 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 10655584 |
| Identification Methods | affinity chromatography technology, anti bait coimmunoprecipitation, fluorescence microscopy |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, FERM_M~PK_Tyr_Ser-Thr, FERM_N_2~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1 |
| Common GO terms | GO:0001525 - angiogenesis GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016477 - cell migration and 5 others more... |
| Homologous interactions | 19 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
