HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: GRDN (Q3V6T2)
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)
Gene: CCDC88A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0030027 - lamellipodium
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 1871
+	Hs
		640182 EPHA1_HUMAN (17-967): 0: 947: 49.28		GRDN_HUMAN (1-1871): 1.42e-146: 501: 100.00
+	Hs
		710604 EPHA3_HUMAN (24-976): 0: 1096: 50.98		MYH9_HUMAN (1117-1871): 5.15e-30: 132: 9.12
+	Hs
		710259 EPHA2_HUMAN (1-976): 0: 1124: 100.00		TRIPB_HUMAN (787-1622): 1.83e-18: 95: 10.35
+	Hs
		270775 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ROCK2_HUMAN (244-1010): 3.07e-09: 64.3: 20.76
+	Hs
		1150960 EPHA6_HUMAN (9-973): 0: 1071: 47.70		TRIPB_HUMAN (787-1622): 1.83e-18: 95: 10.35
+	Hs
		720244 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		GRDN_HUMAN (1-1871): 1.42e-146: 501: 100.00
+	Hs
		439751 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		GRDN_HUMAN (1-1871): 1.42e-146: 501: 100.00
+	Hs
		650461 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		DAPLE_HUMAN (3-1838): 2.67e-101: 365: 45.75
+	Hs
		463552 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		GRDN_HUMAN (1-1871): 1.42e-146: 501: 100.00
+	Hs
		720360 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		MYH2_HUMAN (931-1869): 1.99e-34: 147: 9.40
+	Hs
		463811 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		DAPLE_HUMAN (3-1838): 2.67e-101: 365: 45.75
+	Hs
		650174 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		TRIPB_HUMAN (787-1622): 1.83e-18: 95: 10.35
+	Hs
		587566 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		DESP_HUMAN (244-1208): 1.12e-09: 66.2: 19.09
+	Hs
		465525 IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90		EEA1_HUMAN (1024-1684): 5.16e-12: 73.4: 9.73
+	Hs
		650169 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		EEA1_HUMAN (1024-1684): 5.16e-12: 73.4: 9.73
+	Hs
		463377 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		MYH9_HUMAN (1117-1871): 5.15e-30: 132: 9.12
+	Hs
		64523 HCK_HUMAN (591-880): 1.47e-65: 231: 42.12		CC88B_HUMAN (683-1516): 1.83e-09: 65.3: 11.64
+	Hs
		463314 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		DESP_HUMAN (244-1208): 1.12e-09: 66.2: 19.09