HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: PHLB2 (Q86SQ0)
Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)
Gene: PHLDB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0045296 - cadherin binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 1253
+	Hs
		710339 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PHLB1_HUMAN (21-1252): 2.41e-60: 229: 27.39
+	Hs
		710604 EPHA3_HUMAN (24-976): 0: 1096: 50.98		MYH9_HUMAN (468-1188): 3.76e-24: 112: 9.27
+	Hs
		710307 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PHLB3_HUMAN (507-808): 8.88e-13: 74.7: 22.33
+	Hs
		270775 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ROCK2_HUMAN (699-1134): 2.24e-10: 67.5: 11.90
+	Hs
		463618 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		PHLB2_HUMAN (1-1253): 2.28e-122: 411: 100.00
+	Hs
		720360 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		MYH2_HUMAN (215-1078): 3.02e-29: 129: 9.06
+	Hs
		587566 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		DESP_HUMAN (412-840): 2.67e-10: 67.3: 19.03
+	Hs
		650388 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		SCAPE_HUMAN (381-807): 4.45e-11: 70: 19.56
+	Hs
		463377 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		MYH9_HUMAN (468-1188): 3.76e-24: 112: 9.27
+	Hs
		319045 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		K0754_HUMAN (42-1075): 8.56e-20: 98.6: 9.42
+	Hs
		463314 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		DESP_HUMAN (412-840): 2.67e-10: 67.3: 19.03