HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: S12A6 (Q9UHW9)
Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)
Gene: SLC12A6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 1150
+	Hs
		710595 EPHA2_HUMAN (1-976): 0: 1124: 100.00		S12A7_HUMAN (71-1150): 0: 1058: 69.37
+	Hs
		710144 EPHA2_HUMAN (1-976): 0: 1124: 100.00		S12A2_HUMAN (4-1150): 0: 715: 19.37
+	Hs
		933408 EPHA7_HUMAN (4-974): 0: 1120: 50.15		S12A2_HUMAN (4-1150): 0: 715: 19.37
+	Hs
		932048 EPHA4_HUMAN (1-974): 0: 1110: 50.35		S12A2_HUMAN (4-1150): 0: 715: 19.37
+	Rn
		580512 INSR_RAT (371-873): 1.87e-134: 440: 29.49		S12A7_RAT (71-1150): 0: 1083: 69.56
+	Hs
		463825 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		S12A6_HUMAN (1-1150): 0: 1255: 100.00
+	Hs
		722461 EPHA7_HUMAN (4-974): 0: 1120: 50.15		CTR1_HUMAN (231-668): 7.06e-88: 299: 13.67
+	Hs
		1147395 EPHA7_HUMAN (4-974): 0: 1120: 50.15		CTR3_HUMAN (231-668): 5.66e-82: 282: 13.44
+	Hs
		710181 EPHA2_HUMAN (1-976): 0: 1124: 100.00		LAT1_HUMAN (228-752): 4.38e-80: 273: 11.45
+	Hs
		463841 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		S12A4_HUMAN (100-1150): 0: 1091: 77.68
+	Hs
		463869 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		S12A7_HUMAN (71-1150): 0: 1058: 69.37
+	Hs
		640240 EPHA1_HUMAN (17-967): 0: 947: 49.28		CTR3_HUMAN (231-668): 5.66e-82: 282: 13.44
+	Hs
		463420 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		S12A2_HUMAN (4-1150): 0: 715: 19.37
+	Hs
		650473 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		LAT2_HUMAN (233-750): 9.07e-91: 304: 13.38
+	Hs
		439803 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		CTR3_HUMAN (231-668): 5.66e-82: 282: 13.44
+	Hs
		465589 IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90		CTR3_HUMAN (231-668): 5.66e-82: 282: 13.44
+	Hs
		463414 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		CTR2_HUMAN (229-668): 1.63e-93: 315: 15.46
+	Hs
		463460 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		LAT1_HUMAN (228-752): 4.38e-80: 273: 11.45