HitPredict

Interactor 1: PLK1 (P34331)
Serine/threonine-protein kinase plk-1 (EC 2.7.11.21) (Polo-like kinase 1)
Gene: plk-1

Interactor 2: SPD5 (P91349)
Spindle-defective protein 5
Gene: spd-5

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.701

Property	Details
Experiments	28575670, 25977552, 29222174, 38456967
Identification Methods	pull down, enzymatic study, protein kinase assay, fluorescence microscopy
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0007052 - mitotic spindle organization GO:0007098 - centrosome cycle
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 649 Ce			1 1198
+	Hs
		1268102 PLK2_HUMAN (23-592): 4.11e-157: 469: 33.66		MY18A_HUMAN (67-697): 8.57e-10: 65.5: 11.03
+	Ce
		106141 G5EDL3_CAEEL (38-278): 2.48e-40: 152: 34.57		SPD5_CAEEL (1-1198): 5.91e-71: 261: 100.00
+	Hs
		129044 PLK4_HUMAN (38-284): 4.21e-51: 192: 40.16		CP250_HUMAN (1-1076): 3.09e-35: 149: 8.43