Protein: LHX4
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)

Gene: LHX4
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q969G2

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001890 - placenta development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1199128

LDB1
LIM domain-binding protein 1

7

20

High-throughput

0.965

High

1281161

ISL2
Insulin gene enhancer protein ISL-2

6

18

Small-scale

0.947

High

899929

ISL1
Insulin gene enhancer protein ISL-1

5

19

High-throughput

0.928

High

656412

PIT1
Pituitary-specific positive transcription factor 1

2

14

High-throughput

0.783

High

960051

HXC5
Homeobox protein Hox-C5

2

11

High-throughput

0.783

High

903763

LMO4
LIM domain transcription factor LMO4

2

19

High-throughput

0.754

High

1281212

ORC6
Origin recognition complex subunit 6

5

2

High-throughput

0.717

High

946655

SSBP2
Single-stranded DNA-binding protein 2

5

20

High-throughput

0.714

High

1281178

SSBP4
Single-stranded DNA-binding protein 4

4

20

High-throughput

0.694

High

1251418

LMO3
LIM domain only protein 3

1

19

High-throughput

0.691

High

1281179

SSBP3
Single-stranded DNA-binding protein 3

4

20

High-throughput

0.691

High

1281177

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

3

1

High-throughput

0.675

High

203157

P52K
52 kDa repressor of the inhibitor of the protein kinase

3

2

High-throughput

0.667

High

1035533

SMAD4
Mothers against decapentaplegic homolog 4

3

3

High-throughput

0.667

High

1224629

ABI1
Abl interactor 1

3

11

High-throughput

0.667

High

1281187

CHM1A
Charged multivesicular body protein 1a

3

2

High-throughput

0.667

High

1281193

ABI2
Abl interactor 2

3

16

High-throughput

0.667

High

210841

LDB2
LIM domain-binding protein 2

1

20

Small-scale

0.656

High

1147469

ARID2
AT-rich interactive domain-containing protein 2

3

20

High-throughput

0.656

High

632843

TYY1
Transcriptional repressor protein YY1

3

14

High-throughput

0.653

High

1281209

T22D4
TSC22 domain family protein 4

2

4

High-throughput

0.628

High

551233

ITF2
Transcription factor 4

1

5

High-throughput

0.621

High

1043721

ASPP2
Apoptosis-stimulating of p53 protein 2

1

20

High-throughput

0.621

High

966988

SATB1
DNA-binding protein SATB1

1

7

High-throughput

0.618

High

1059593

MEF2D
Myocyte-specific enhancer factor 2D

1

3

High-throughput

0.618

High

1218694

MGAP
MAX gene-associated protein

1

6

High-throughput

0.618

High

1281166

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

14

High-throughput

0.618

High

1281184

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

12

High-throughput

0.618

High

1281195

LHX3
LIM/homeobox protein Lhx3

1

19

Small-scale

0.618

High

1281197

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.618

High

1281199

ZHX1
Zinc fingers and homeoboxes protein 1

1

20

High-throughput

0.618

High

1281203

SATB2
DNA-binding protein SATB2

1

7

High-throughput

0.618

High

1281216

ZHX2
Zinc fingers and homeoboxes protein 2

1

17

High-throughput

0.618

High

1169066

ZN574
Zinc finger protein 574

2

6

High-throughput

0.611

High

1281162

CYFP2
Cytoplasmic FMR1-interacting protein 2

2

2

High-throughput

0.611

High

1236214

CA052
UPF0690 protein C1orf52

3

2

High-throughput

0.609

High

1281215

WASF2
Actin-binding protein WASF2

3

8

High-throughput

0.609

High

446731

SNRPA
U1 small nuclear ribonucleoprotein A

2

1

High-throughput

0.606

High

735087

ZNF76
Zinc finger protein 76

2

10

High-throughput

0.606

High

883770

SCND1
SCAN domain-containing protein 1

2

9

High-throughput

0.606

High

960114

CDK3
Cyclin-dependent kinase 3

2

2

High-throughput

0.606

High

1102939

QRIC1
Transcriptional regulator QRICH1

2

18

High-throughput

0.606

High

1235587

ZBTB2
Zinc finger and BTB domain-containing protein 2

2

5

High-throughput

0.606

High

1281188

MYOZ1
Myozenin-1

2

2

High-throughput

0.606

High

1281190

PAR11
Protein mono-ADP-ribosyltransferase PARP11

2

1

High-throughput

0.606

High

1281214

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

0

High-throughput

0.601

High

243150

SH21A
SH2 domain-containing protein 1A

2

7

High-throughput

0.600

High

131736

BCL9
B-cell CLL/lymphoma 9 protein

2

20

High-throughput

0.584

High

1200125

BCL9L
B-cell CLL/lymphoma 9-like protein

2

20

High-throughput

0.584

High

734480

ARL2
ADP-ribosylation factor-like protein 2

2

0

High-throughput

0.580

High

1231888

CENPS
Centromere protein S

2

0

High-throughput

0.580

High

271160

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

1

High-throughput

0.573

High

443228

NFIC
Nuclear factor 1 C-type

1

14

High-throughput

0.561

High

1103519

KLH38
Kelch-like protein 38

2

2

High-throughput

0.553

High

1191928

SEN54
tRNA-splicing endonuclease subunit Sen54

2

1

High-throughput

0.553

High

1238477

BANP
Protein BANP

2

6

High-throughput

0.553

High

1281167

DHRS1
Dehydrogenase/reductase SDR family member 1

2

1

High-throughput

0.553

High

1281172

COR1B
Coronin-1B

2

1

High-throughput

0.553

High

1281181

IN80B
INO80 complex subunit B

2

1

High-throughput

0.553

High

1281204

MARE3
Microtubule-associated protein RP/EB family member 3

2

2

High-throughput

0.553

High

170694

AXIN1
Axin-1

1

4

High-throughput

0.541

High

1281210

PYGO1
Pygopus homolog 1

1

20

High-throughput

0.536

High

1089366

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

4

High-throughput

0.523

High

135146

NFIB
Nuclear factor 1 B-type

1

10

High-throughput

0.515

High

1018251

NFIA
Nuclear factor 1 A-type

1

14

High-throughput

0.515

High

1281205

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

727575

HNF1B
Hepatocyte nuclear factor 1-beta

1

12

High-throughput

0.501

High

1060346

NFIX
Nuclear factor 1 X-type

1

16

High-throughput

0.501

High

1281176

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

2

High-throughput

0.500

High

1033698

IKZF1
DNA-binding protein Ikaros

1

18

High-throughput

0.481

High

1085273

NRF1
Nuclear respiratory factor 1

1

4

High-throughput

0.481

High

1166949

ATL4
ADAMTS-like protein 4

1

3

High-throughput

0.481

High

1205168

Z354C
Zinc finger protein 354C

1

7

High-throughput

0.481

High

1240402

TXND5
Thioredoxin domain-containing protein 5

1

1

High-throughput

0.481

High

146263

ARI1A
AT-rich interactive domain-containing protein 1A

1

18

High-throughput

0.479

High

152677

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

164255

ZN609
Zinc finger protein 609

1

10

High-throughput

0.479

High

170439

TIF1A
Transcription intermediary factor 1-alpha

1

9

High-throughput

0.479

High

183145

KDM6A
Lysine-specific demethylase 6A

1

5

High-throughput

0.479

High

261561

NCOR1
Nuclear receptor corepressor 1

1

18

High-throughput

0.479

High

265694

E2F6
Transcription factor E2F6

1

3

High-throughput

0.479

High

449787

HMGB1
High mobility group protein B1

1

20

High-throughput

0.479

High

525328

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

15

High-throughput

0.479

High

550422

ZEP1
Zinc finger protein 40

1

20

High-throughput

0.479

High

643381

HMGB2
High mobility group protein B2

1

20

High-throughput

0.479

High

722274

RFC1
Replication factor C subunit 1

1

4

High-throughput

0.479

High

824253

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

17

High-throughput

0.479

High

846841

SMCA2
Probable global transcription activator SNF2L2

1

12

High-throughput

0.479

High

847048

SMCA4
Transcription activator BRG1

1

13

High-throughput

0.479

High

868663

ATX1
Ataxin-1

1

5

High-throughput

0.479

High

952848

FOXK1
Forkhead box protein K1

1

9

High-throughput

0.479

High

958986

TFAM
Transcription factor A, mitochondrial

1

17

High-throughput

0.479

High

980633

TLE1
Transducin-like enhancer protein 1

1

12

High-throughput

0.479

High

987794

GABPA
GA-binding protein alpha chain

1

6

High-throughput

0.479

High

993530

TLE5
TLE family member 5

1

10

High-throughput

0.479

High

1040822

PWP1
Periodic tryptophan protein 1 homolog

1

3

High-throughput

0.479

High

1075385

NCOA2
Nuclear receptor coactivator 2

1

5

High-throughput

0.479

High

1077580

ELF2
ETS-related transcription factor Elf-2

1

6

High-throughput

0.479

High

1118878

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

8

High-throughput

0.479

High

1139728

ZMYM4
Zinc finger MYM-type protein 4

1

11

High-throughput

0.479

High

1159796

NFRKB
Nuclear factor related to kappa-B-binding protein

1

8

High-throughput

0.479

High

1173202

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

1189260

POGZ
Pogo transposable element with ZNF domain

1

8

High-throughput

0.479

High

1199179

PB1
Protein polybromo-1

1

16

High-throughput

0.479

High

1217550

FOXP4
Forkhead box protein P4

1

14

High-throughput

0.479

High

1225006

TAF1L
Transcription initiation factor TFIID subunit 1-like

1

16

High-throughput

0.479

High

1243832

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

1244285

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

1245583

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

1259957

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

1260815

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

8

High-throughput

0.479

High

1270582

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

1270662

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1271436

KAT2A
Histone acetyltransferase KAT2A

1

10

High-throughput

0.479

High

1272968

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

18

High-throughput

0.479

High

1281160

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

5

High-throughput

0.479

High

1281163

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

12

High-throughput

0.479

High

1281168

PHF12
PHD finger protein 12

1

12

High-throughput

0.479

High

1281169

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1281170

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1281171

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

8

High-throughput

0.479

High

1281175

PCGF1
Polycomb group RING finger protein 1

1

7

High-throughput

0.479

High

1281180

GTPB4
GTP-binding protein 4

1

3

High-throughput

0.479

High

1281182

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

1

High-throughput

0.479

High

1281183

ZN644
Zinc finger protein 644

1

8

High-throughput

0.479

High

1281189

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

1281191

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.479

High

1281194

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

7

High-throughput

0.479

High

1281202

TRI33
E3 ubiquitin-protein ligase TRIM33

1

10

High-throughput

0.479

High

1281211

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

1281213

NCOR2
Nuclear receptor corepressor 2

1

19

High-throughput

0.479

High

1200445

Q86UY0
protein disulfide-isomerase

1

1

High-throughput

0.470

High

1081817

SSX1
Protein SSX1

1

0

Small-scale

0.460

High

245624

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

0

High-throughput

0.458

High

899534

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

1028192

GPS2
G protein pathway suppressor 2

1

0

High-throughput

0.458

High

1281196

IF172
Intraflagellar transport protein 172 homolog

1

1

Small-scale

0.457

High

279664

FLOT1
Flotillin-1

1

3

High-throughput

0.457

High

787768

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.457

High

281034

KRT38
Keratin, type I cuticular Ha8

1

19

High-throughput

0.439

High

995104

GOGA2
Golgin subfamily A member 2

1

10

High-throughput

0.439

High

1149267

K1C40
Keratin, type I cytoskeletal 40

1

18

High-throughput

0.439

High

1281200

UBQL1
Ubiquilin-1

1

4

High-throughput

0.439

High

1184641

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

2

High-throughput

0.437

High

1218164

CEP97
Centrosomal protein of 97 kDa

1

2

High-throughput

0.437

High

1230881

ZN687
Zinc finger protein 687

1

5

High-throughput

0.437

High

1281173

CG050
Uncharacterized protein C7orf50

1

3

High-throughput

0.437

High

1281174

PYGO2
Pygopus homolog 2

1

11

High-throughput

0.437

High

1281185

GRPE1
GrpE protein homolog 1, mitochondrial

1

1

High-throughput

0.437

High

1281192

RBM28
RNA-binding protein 28

1

3

High-throughput

0.437

High

1281201

RL26L
Ribosomal protein uL24-like

1

2

High-throughput

0.437

High

1281206

DDX52
Probable ATP-dependent RNA helicase DDX52

1

1

High-throughput

0.437

High

1281207

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.437

High

1122468

ACTBL
Beta-actin-like protein 2

1

7

High-throughput

0.407

High

1016738

CETN1
Centrin-1

2

0

High-throughput

0.328

High

276599

TPC6A
Trafficking protein particle complex subunit 6A

2

0

High-throughput

0.316

High

887200

DJB13
DnaJ homolog subfamily B member 13

2

0

High-throughput

0.316

High

1129893

DCA10
DDB1- and CUL4-associated factor 10

2

0

High-throughput

0.316

High

1135028

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

2

0

High-throughput

0.316

High

1190344

TRM11
tRNA

2

0

High-throughput

0.316

High

1223593

BD1L2
Biorientation of chromosomes in cell division protein 1-like 2

2

0

High-throughput

0.316

High

1281164

ERO1A
ERO1-like protein alpha

2

0

High-throughput

0.316

High

1281186

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.316

High

1281208

WASC3
WASH complex subunit 3

2

0

High-throughput

0.316

High

1281198

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.279

Low

1159736

FDX2
Ferredoxin-2, mitochondrial

1

0

High-throughput

0.268

Low

174305

TELT
Telethonin

1

0

High-throughput

0.265

Low

1281165

DCAF5
DDB1- and CUL4-associated factor 5

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024