HitPredict

Interactor 1: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Interactor 2: FHL3 (Q13643)
Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2)
Gene: FHL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 882 Hs			1 280
+	Hs
		713948 PML_HUMAN (1-882): 0: 902: 100.00		PAXI_HUMAN (3-218): 2.69e-72: 234: 28.70
+	Hs
		713945 PML_HUMAN (1-882): 0: 902: 100.00		LIMS1_HUMAN (37-278): 1.09e-45: 158: 23.48
+	Hs
		714328 PML_HUMAN (1-882): 0: 902: 100.00		LPP_HUMAN (3-153): 6.55e-38: 142: 29.38
+	Hs
		159156 PML_HUMAN (1-882): 0: 902: 100.00		ABLM1_HUMAN (126-277): 3.11e-25: 106: 20.92
+	Hs
		714112 PML_HUMAN (1-882): 0: 902: 100.00		FHL2_HUMAN (4-156): 7.56e-25: 101: 26.45
+	Hs
		1099868 TIF1B_HUMAN (7-593): 4.28e-70: 250: 14.24		FHL3_HUMAN (1-280): 8.02e-78: 239: 100.00
+	Hs
		1116623 TRI33_HUMAN (56-554): 2.79e-67: 246: 15.63		FHL3_HUMAN (1-280): 8.02e-78: 239: 100.00
+	Mm
		1408964 TRIM8_MOUSE (51-538): 1.43e-67: 237: 14.61		FHL3_MOUSE (1-280): 1.63e-73: 228: 94.46
+	Hs
		870123 TIF1B_HUMAN (7-593): 4.28e-70: 250: 14.24		LIMS1_HUMAN (37-278): 1.09e-45: 158: 23.48
+	Hs
		1125187 TRI25_HUMAN (42-366): 3.77e-56: 207: 16.67		PDLI5_HUMAN (3-155): 2.4e-47: 168: 28.76
+	Hs
		1393041 TRI39_HUMAN (48-447): 3.49e-53: 195: 11.89		PDLI5_HUMAN (3-155): 2.4e-47: 168: 28.76
+	Hs
		1393034 TRI56_HUMAN (34-536): 2.95e-51: 194: 18.60		PDLI5_HUMAN (3-155): 2.4e-47: 168: 28.76
+	Hs
		1393036 TRI55_HUMAN (48-500): 1.34e-50: 189: 13.07		PDLI5_HUMAN (3-155): 2.4e-47: 168: 28.76
+	Hs
		186573 TRI18_HUMAN (48-411): 5.89e-49: 186: 13.73		PDLI5_HUMAN (3-155): 2.4e-47: 168: 28.76
+	Hs
		1099881 TIF1B_HUMAN (7-593): 4.28e-70: 250: 14.24		FHL2_HUMAN (4-156): 7.56e-25: 101: 26.45
+	Hs
		1278490 TRI55_HUMAN (48-500): 1.34e-50: 189: 13.07		LIMS2_HUMAN (40-278): 3.28e-45: 157: 25.41
+	Hs
		623336 RO52_HUMAN (44-414): 7.74e-53: 193: 13.46		FHL1_HUMAN (66-279): 2.76e-43: 151: 29.17
+	Hs
		623471 RO52_HUMAN (44-414): 7.74e-53: 193: 13.46		LPP_HUMAN (3-153): 6.55e-38: 142: 29.38
+	Hs
		1123097 TRI55_HUMAN (48-500): 1.34e-50: 189: 13.07		FHL2_HUMAN (4-156): 7.56e-25: 101: 26.45