HitPredict

Interactor 1: GNA11 (P29992)
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha)
Gene: GNA11

Interactor 2: GBG2 (P59768)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
Gene: GNG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0045202 - synapse GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 71
+	Hs
		893472 GNAQ_HUMAN (1-359): 1.52e-168: 475: 90.25		GBG2_HUMAN (1-71): 3.59e-29: 100: 100.00
+	Hs
		893466 GNAQ_HUMAN (1-359): 1.52e-168: 475: 90.25		GBG4_HUMAN (1-71): 6.57e-28: 97: 77.47
+	Hs
		893479 GNAQ_HUMAN (1-359): 1.52e-168: 475: 90.25		GBG3_HUMAN (4-71): 3.15e-27: 95.1: 79.41
+	Hs
		893542 GNAQ_HUMAN (1-359): 1.52e-168: 475: 90.25		GBG8_HUMAN (3-71): 8.54e-26: 91.7: 71.01
+	Hs
		716000 GNA11_HUMAN (1-359): 3.26e-165: 467: 100.00		GBG4_HUMAN (1-71): 6.57e-28: 97: 77.47
+	Hs
		716019 GNA11_HUMAN (1-359): 3.26e-165: 467: 100.00		GBG3_HUMAN (4-71): 3.15e-27: 95.1: 79.41
+	Hs
		893537 GNAQ_HUMAN (1-359): 1.52e-168: 475: 90.25		GBG12_HUMAN (3-71): 4.48e-24: 87: 62.32
+	Hs
		948054 GNAI1_HUMAN (7-358): 9.59e-163: 460: 51.70		GBG2_HUMAN (1-71): 3.59e-29: 100: 100.00
+	Hs
		716061 GNA11_HUMAN (1-359): 3.26e-165: 467: 100.00		GBG8_HUMAN (3-71): 8.54e-26: 91.7: 71.01
+	Hs
		893467 GNAQ_HUMAN (1-359): 1.52e-168: 475: 90.25		GBG10_HUMAN (4-71): 4.36e-22: 82: 52.94
+	Hs
		893553 GNAI1_HUMAN (7-358): 9.59e-163: 460: 51.70		GBG4_HUMAN (1-71): 6.57e-28: 97: 77.47
+	Hs
		989826 GNAI1_HUMAN (7-358): 9.59e-163: 460: 51.70		GBG3_HUMAN (4-71): 3.15e-27: 95.1: 79.41
+	Hs
		893480 GNAQ_HUMAN (1-359): 1.52e-168: 475: 90.25		GBG5_HUMAN (4-71): 4.13e-21: 79.7: 48.53
+	Hs
		893478 GNAQ_HUMAN (1-359): 1.52e-168: 475: 90.25		GBG1_HUMAN (11-70): 2.95e-20: 77.8: 38.33
+	Hs
		243468 GNAI1_HUMAN (7-358): 9.59e-163: 460: 51.70		GBG7_HUMAN (4-71): 4.44e-25: 89.7: 70.59
+	Hs
		716001 GNA11_HUMAN (1-359): 3.26e-165: 467: 100.00		GBG10_HUMAN (4-71): 4.36e-22: 82: 52.94
+	Hs
		716020 GNA11_HUMAN (1-359): 3.26e-165: 467: 100.00		GBG5_HUMAN (4-71): 4.13e-21: 79.7: 48.53
+	Hs
		716018 GNA11_HUMAN (1-359): 3.26e-165: 467: 100.00		GBG1_HUMAN (11-70): 2.95e-20: 77.8: 38.33
+	Hs
		893567 GNAI1_HUMAN (7-358): 9.59e-163: 460: 51.70		GBG10_HUMAN (4-71): 4.36e-22: 82: 52.94
+	Hs
		989827 GNAI1_HUMAN (7-358): 9.59e-163: 460: 51.70		GBG5_HUMAN (4-71): 4.13e-21: 79.7: 48.53