HitPredict

Interactor 1: GCS1 (P35197)
ADP-ribosylation factor GTPase-activating protein GCS1 (ARF GAP GCS1)
Gene: GCS1

Interactor 2: ARL1 (P38116)
ADP-ribosylation factor-like protein 1 (Arf-like GTPase 1)
Gene: ARL1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	15975906, 24706946, 22767516
Identification Methods	two hybrid, enzymatic study, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Arf~ArfGap
Common GO terms	GO:0005802 - trans-Golgi network GO:0005829 - cytosol GO:0043001 - Golgi to plasma membrane protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Sc			1 183
+	Sc
		503072 GCS1_YEAST (1-352): 1.56e-107: 320: 100.00		ARF1_YEAST (1-180): 1.36e-64: 197: 55.56
+	Hs
		776157 ARFG1_HUMAN (6-352): 3.67e-74: 236: 25.14		ARL1_HUMAN (17-182): 1.28e-74: 223: 65.06
+	Hs
		912911 ACAP2_HUMAN (3-260): 2.53e-69: 232: 20.69		ARF6_HUMAN (1-180): 9.98e-74: 221: 51.67
+	Hs
		912985 SMAP1_HUMAN (3-334): 7.52e-67: 219: 19.01		ARF6_HUMAN (1-180): 9.98e-74: 221: 51.67
+	Hs
		950523 ARFG1_HUMAN (6-352): 3.67e-74: 236: 25.14		ARF1_HUMAN (1-182): 6.48e-64: 196: 56.04
+	At
		285978 AGD7_ARATH (11-351): 3.55e-73: 235: 25.19		ARF2B_ARATH (1-178): 7.23e-64: 196: 57.30
+	Hs
		912909 ACAP1_HUMAN (1-257): 7.53e-61: 209: 19.55		ARF6_HUMAN (1-180): 9.98e-74: 221: 51.67
+	Hs
		950654 ARFG2_HUMAN (1-277): 1.7e-55: 191: 20.14		ARF5_HUMAN (1-181): 1.91e-76: 228: 53.04
+	Hs
		897381 SMAP1_HUMAN (3-334): 7.52e-67: 219: 19.01		ARF3_HUMAN (1-182): 4.57e-64: 196: 56.04
+	Hs
		574718 SMAP2_HUMAN (3-325): 1.11e-65: 215: 17.46		ARF4_HUMAN (1-181): 7.3e-65: 198: 52.49
+	Sc
		744353 GLO3_YEAST (6-346): 2.23e-55: 190: 18.61		ARL1_YEAST (1-183): 1.33e-74: 223: 100.00
+	Hs
		897390 SMAP2_HUMAN (3-325): 1.11e-65: 215: 17.46		ARF3_HUMAN (1-182): 4.57e-64: 196: 56.04
+	Hs
		913052 AGAP3_HUMAN (2-239): 1.37e-52: 188: 18.46		ARF6_HUMAN (1-180): 9.98e-74: 221: 51.67
+	Hs
		574712 ARFG2_HUMAN (1-277): 1.7e-55: 191: 20.14		ARF4_HUMAN (1-181): 7.3e-65: 198: 52.49
+	Sc
		580854 GLO3_YEAST (6-346): 2.23e-55: 190: 18.61		ARF2_YEAST (1-181): 2.61e-65: 199: 53.59
+	Sc
		503086 GLO3_YEAST (6-346): 2.23e-55: 190: 18.61		ARF1_YEAST (1-180): 1.36e-64: 197: 55.56
+	Hs
		897383 ARFG2_HUMAN (1-277): 1.7e-55: 191: 20.14		ARF3_HUMAN (1-182): 4.57e-64: 196: 56.04
+	Hs
		950522 ARFG2_HUMAN (1-277): 1.7e-55: 191: 20.14		ARF1_HUMAN (1-182): 6.48e-64: 196: 56.04
+	Hs
		574756 ARFG3_HUMAN (5-187): 6.35e-53: 184: 27.81		ARF4_HUMAN (1-181): 7.3e-65: 198: 52.49
+	Hs
		897406 ARFG3_HUMAN (5-187): 6.35e-53: 184: 27.81		ARF3_HUMAN (1-182): 4.57e-64: 196: 56.04