HitPredict

Interactor 1: CDC27 (P30260)
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)
Gene: CDC27

Interactor 2: CDC23 (Q9UJX2)
Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)
Gene: CDC23

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 12956947, 20686030, 27114510, 27173435, 32152539, 32076268, 32934012, 10922056, 35271311, 35952650, 14657031, 22193957, 17942546, 16364912, 22792066, 21043528, 22280307, 16648845, 26496610, 20360068
Identification Methods affinity chromatography technology, biochemical, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ANAPC3~TPR_11, ANAPC3~TPR_8, TPR_1~TPR_11, TPR_1~TPR_8, ANAPC8~TPR_8, TPR_11~TPR_8, TPR_8~TPR_8
Common GO terms GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005829 - cytosol
GO:0007091 - metaphase/anaphase transition of mitotic cell cycle
GO:0007346 - regulation of mitotic cell cycle
and 7 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 824
Hs

1 597
+ Xl
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Xl
+ Xl
+ Xl
+ Hs
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Sp
+ Sp

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Last updated: 11Aug2025