Interactor 1: CDC27 (P30260)
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)
Gene: CDC27

Interactor 2: APC7 (Q9UJX3)
Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)
Gene: ANAPC7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 25490258, 27173435, 31839598, 23160376, 12956947, 20686030, 25306918, 26811472, 27114510, 28404789, 32152539, 32076268, 10922056, 35271311, 34942119, 14657031, 22193957, 17942546, 16364912, 21043528 and 1 others

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Identification Methods affinity chromatography technology, biochemical, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ANAPC3~TPR_8, TPR_1~TPR_16, TPR_1~TPR_8, TPR_16~TPR_8, TPR_8~TPR_8
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005819 - spindle
GO:0005829 - cytosol
and 10 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 824
Hs

1 565
+ Mm
+ Xl
+ Hs
+ Hs
+ Hs
+ Hs
+ Xl
+ Xl
+ Xl
+ Hs
+ Dm
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Sp
+ Sp

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Last updated: 11Aug2025