HitPredict

Interactor 1: VGFR1 (P35969)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Embryonic receptor kinase 2) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)
Gene: Flt1

Interactor 2: VEGFB (P49766)
Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF)
Gene: VEGFB

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11122379
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDGF~ig, Ig_3~PDGF
Common GO terms	GO:0001666 - response to hypoxia GO:0002040 - sprouting angiogenesis GO:0005615 - extracellular space GO:0030154 - cell differentiation GO:0048010 - vascular endothelial growth factor receptor signaling pathway
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1333 Mm			1 207
+	Hs
		572600 VGFR1_HUMAN (21-1332): 0: 959: 81.49		VEGFB_HUMAN (23-207): 1.78e-74: 225: 87.03
+	Mm
		729710 VGFR1_MOUSE (1-1333): 0: 1019: 100.00		PLGF_MOUSE (4-126): 2.53e-47: 154: 35.20
+	Mm
		729713 VGFR1_MOUSE (1-1333): 0: 1019: 100.00		VEGFA_MOUSE (19-140): 8.66e-42: 146: 40.65
+	Hs
		572599 VGFR1_HUMAN (21-1332): 0: 959: 81.49		PLGF_HUMAN (4-151): 1.8e-53: 172: 33.55
+	Hs
		549553 VGFR1_HUMAN (21-1332): 0: 959: 81.49		VEGFA_HUMAN (19-140): 3.28e-43: 150: 39.84
+	Dm
		112227 M9MRE1_DROME (26-1254): 0: 740: 25.66		Q9BLX1_DROME (45-132): 1.84e-26: 104: 25.00
+	Dm
		1182097 Q7KTI7_DROME (26-1254): 0: 739: 25.61		Q9BLX1_DROME (45-132): 1.84e-26: 104: 25.00
+	Mm
		729414 VGFR2_MOUSE (2-650): 1.1e-58: 224: 13.37		VEGFA_MOUSE (19-140): 8.66e-42: 146: 40.65
+	Hs
		729247 VGFR3_HUMAN (1-669): 1.25e-50: 198: 11.47		VEGFC_HUMAN (16-146): 2.44e-45: 156: 28.47
+	Mm
		729406 VGFR3_MOUSE (1-445): 6.24e-43: 173: 12.60		VEGFC_MOUSE (14-146): 7.33e-49: 166: 28.06
+	Hs
		217378 VGFR3_HUMAN (1-669): 1.25e-50: 198: 11.47		VEGFD_HUMAN (23-140): 3.05e-38: 136: 27.87
+	Hs
		729626 VGFR2_HUMAN (1-121): 1.31e-16: 88.1: 12.21		VEGFC_HUMAN (16-146): 2.44e-45: 156: 28.47
+	Hs
		350950 PGFRA_HUMAN (1-415): 4.52e-27: 121: 12.31		PDGFB_HUMAN (45-150): 2.38e-33: 121: 28.57
+	Hs
		549560 VGFR2_HUMAN (1-121): 1.31e-16: 88.1: 12.21		VEGFA_HUMAN (19-140): 3.28e-43: 150: 39.84
+	Hs
		376364 PGFRA_HUMAN (1-415): 4.52e-27: 121: 12.31		PDGFA_HUMAN (37-141): 4.11e-29: 109: 25.23
+	Hs
		217379 VGFR2_HUMAN (1-121): 1.31e-16: 88.1: 12.21		VEGFD_HUMAN (23-140): 3.05e-38: 136: 27.87
+	Hs
		350948 PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94		PDGFB_HUMAN (45-150): 2.38e-33: 121: 28.57
+	Hs
		376361 PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94		PDGFA_HUMAN (37-141): 4.11e-29: 109: 25.23