HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: SPD2A (Q5TCZ1)
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Gene: SH3PXD2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.735

Property	Details
Experiments	33961781, 35271311, 36931259, 24255178, 28514442, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1133
+	Hs
		971621 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		SPD2A_HUMAN (1-1133): 2.89e-178: 555: 100.00
+	Hs
		990328 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SPD2A_HUMAN (1-1133): 2.89e-178: 555: 100.00
+	Mm
		313306 1433E_MOUSE (3-243): 4.41e-144: 405: 65.43		SPD2A_MOUSE (1-1133): 2.79e-171: 536: 90.91
+	Hs
		971817 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		SH3R3_HUMAN (389-1130): 1.21e-34: 145: 9.79
+	Hs
		730084 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		SH3R3_HUMAN (389-1130): 1.21e-34: 145: 9.79
+	Hs
		971711 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		SH3R1_HUMAN (335-1130): 1.31e-26: 119: 10.68
+	Hs
		730005 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		SH3R1_HUMAN (335-1130): 1.31e-26: 119: 10.68
+	Hs
		990418 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SH3R1_HUMAN (335-1130): 1.31e-26: 119: 10.68
+	Hs
		971672 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		DNMBP_HUMAN (842-1131): 3.37e-13: 76.7: 12.30
+	Hs
		729973 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		DNMBP_HUMAN (842-1131): 3.37e-13: 76.7: 12.30
+	Hs
		990380 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DNMBP_HUMAN (842-1131): 3.37e-13: 76.7: 12.30
+	Hs
		971514 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		ARHG7_HUMAN (974-1131): 2.45e-10: 67.1: 12.58
+	Hs
		729825 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		ARHG7_HUMAN (974-1131): 2.45e-10: 67.1: 12.58
+	Hs
		971599 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		SH319_HUMAN (306-969): 9.96e-09: 61.7: 10.64
+	Hs
		729897 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		SH319_HUMAN (306-969): 9.96e-09: 61.7: 10.64
+	Mm
		990056 1433Z_MOUSE (3-244): 3.15e-142: 399: 88.02		ARHG7_MOUSE (793-1090): 7.75e-10: 65.4: 17.76
+	Mm
		1423751 1433B_MOUSE (1-246): 5.58e-141: 396: 98.78		ARHG7_MOUSE (793-1090): 7.75e-10: 65.4: 17.76
+	Hs
		990304 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SH319_HUMAN (306-969): 9.96e-09: 61.7: 10.64
+	Hs
		572782 1433T_HUMAN (3-244): 3.25e-127: 361: 81.82		NCF1_HUMAN (411-661): 7.25e-15: 80.2: 15.95
+	Hs
		690993 1433T_HUMAN (3-244): 3.25e-127: 361: 81.82		ARHG7_HUMAN (974-1131): 2.45e-10: 67.1: 12.58