HitPredict

Interactor 1: ARP2 (P32381)
Actin-related protein 2 (Actin-like protein ARP2) (Actin-like protein 2)
Gene: ARP2

Interactor 2: MYO5 (Q04439)
Myosin-5 (Actin-dependent myosin-I MYO5) (Class I unconventional myosin MYO5) (Type I myosin MYO5)
Gene: MYO5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.891

Property	Details
Experiments	10648569, 18467557, 12429847, 38367669
Identification Methods	affinity chromatography technology, protein complementation assay, pull down, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Actin~Myosin_head
Common GO terms	GO:0005524 - ATP binding GO:0015629 - actin cytoskeleton GO:0030479 - actin cortical patch
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 391 Sc			1 1219
+	Sc
		736083 ARP2_YEAST (1-391): 0: 805: 100.00		MYO3_YEAST (1-1205): 0: 1076: 72.08
+	Sc
		948648 ACT_YEAST (1-389): 0: 557: 44.87		MYO5_YEAST (1-1219): 0: 1117: 100.00
+	Sp
		1463035 ARP2_SCHPO (6-391): 0: 590: 72.80		MYO1_SCHPO (1-1219): 0: 1035: 51.49
+	Rn
		953311 ACTB_RAT (2-389): 0: 566: 46.39		MYH10_RAT (2-1044): 0: 1033: 25.02
+	Hs
		773154 ACTC_HUMAN (2-389): 0: 559: 45.88		MYH10_HUMAN (2-1099): 0: 1036: 24.50
+	Hs
		773153 ACTH_HUMAN (2-389): 0: 556: 45.36		MYH10_HUMAN (2-1099): 0: 1036: 24.50
+	Mm
		953280 ACTB_MOUSE (2-389): 0: 566: 46.39		MYH9_MOUSE (7-1048): 0: 1025: 24.25
+	Rn
		953303 ACTB_RAT (2-389): 0: 566: 46.39		MYH9_RAT (7-1034): 0: 1022: 24.19
+	Mm
		977876 ACTA_MOUSE (2-389): 0: 558: 45.62		MYH6_MOUSE (2-1119): 0: 1018: 24.64
+	Hs
		123656 ACTG_HUMAN (2-389): 0: 566: 46.13		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		123657 ACTC_HUMAN (2-389): 0: 559: 45.88		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		123658 ACTS_HUMAN (2-389): 0: 559: 45.62		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		227842 ACTB_HUMAN (2-389): 0: 566: 46.39		MYO1B_HUMAN (36-730): 5.22e-171: 538: 39.72
+	Hs
		227848 ACTC_HUMAN (2-389): 0: 559: 45.88		MYO1B_HUMAN (36-730): 5.22e-171: 538: 39.72
+	Hs
		318299 ACTB_HUMAN (2-389): 0: 566: 46.39		MYO1D_HUMAN (35-766): 3.12e-167: 524: 39.69
+	Hs
		318306 ACTC_HUMAN (2-389): 0: 559: 45.88		MYO1D_HUMAN (35-766): 3.12e-167: 524: 39.69
+	Hs
		993397 ACTG_HUMAN (2-389): 0: 566: 46.13		MYO5A_HUMAN (712-1118): 9.79e-09: 62.1: 8.22