HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	26186194, 27880917, 28514442, 30344098, 33961781, 26617989, 24366813
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, PDZ~STPPase_N
Common GO terms	GO:0098793 - presynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Hs			1 1630
+	Hs
		905890 PP1A_HUMAN (1-323): 0: 579: 90.66		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		906454 PP1B_HUMAN (1-322): 0: 560: 86.89		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		738129 PP1G_HUMAN (1-323): 0: 603: 100.00		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		906202 PP1A_HUMAN (1-323): 0: 579: 90.66		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		906638 PP1B_HUMAN (1-322): 0: 560: 86.89		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		738009 PP1G_HUMAN (1-323): 0: 603: 100.00		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Dm
		524646 PP12_DROME (5-303): 0: 551: 93.31		SUR8_DROME (85-565): 1.98e-85: 295: 23.77
+	Hs
		906110 PP1A_HUMAN (1-323): 0: 579: 90.66		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Mm
		906292 PP1A_MOUSE (1-323): 0: 579: 90.36		LRRC1_MOUSE (1-277): 1e-67: 240: 32.49
+	Hs
		906581 PP1B_HUMAN (1-322): 0: 560: 86.89		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Dm
		524622 PP12_DROME (5-303): 0: 551: 93.31		SCRIB_DROME (1-258): 6.81e-66: 249: 37.98
+	Mm
		906274 PP1A_MOUSE (1-323): 0: 579: 90.36		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Mm
		906652 PP1B_MOUSE (1-322): 0: 560: 86.89		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Mm
		926531 PP1G_MOUSE (1-323): 0: 602: 99.69		DLG3_MOUSE (724-947): 3.57e-19: 96.3: 31.23
+	Mm
		915328 PP2AB_MOUSE (8-312): 2.02e-178: 497: 46.73		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		737775 PP1G_HUMAN (1-323): 0: 603: 100.00		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		905921 PP1A_HUMAN (1-323): 0: 579: 90.66		DLG2_HUMAN (587-879): 1.21e-20: 101: 18.67
+	Hs
		906059 PP1A_HUMAN (1-323): 0: 579: 90.66		DLG3_HUMAN (724-947): 1.74e-19: 97.4: 31.23
+	Hs
		737994 PP1G_HUMAN (1-323): 0: 603: 100.00		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Hs
		906094 PP1A_HUMAN (1-323): 0: 579: 90.66		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06