HitPredict

Interactor 1: PAN1 (P32521)
Actin cytoskeleton-regulatory complex protein PAN1 (Mitochondrial distribution of proteins protein 3)
Gene: PAN1

Interactor 2: ENT1 (Q12518)
Epsin-1
Gene: ENT1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.684

Property	Details
Experiments	9531549, 12529323, 32400111, 37968396
Identification Methods	two hybrid, fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000147 - actin cortical patch assembly GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005935 - cellular bud neck GO:0006897 - endocytosis and 1 others more... GO:0043332 - mating projection tip
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1480 Sc			1 454
+	Sc
		757731 EDE1_YEAST (161-1466): 3.13e-45: 181: 11.60		ENT1_YEAST (1-454): 1.56e-123: 368: 100.00
+	Hs
		1431383 EHD1_HUMAN (232-689): 1.31e-56: 208: 15.40		EPN3_HUMAN (2-435): 7.08e-108: 334: 26.02
+	Mm
		1282820 EHD1_MOUSE (232-689): 1.3e-55: 205: 15.40		EPN1_MOUSE (2-454): 9.1e-109: 334: 21.75
+	Hs
		1434401 EHD1_HUMAN (232-689): 1.31e-56: 208: 15.40		EPN1_HUMAN (2-454): 2.23e-107: 331: 21.10
+	Hs
		1431386 EHD2_HUMAN (229-695): 2.89e-55: 204: 14.52		EPN3_HUMAN (2-435): 7.08e-108: 334: 26.02
+	Hs
		1453486 EHD2_HUMAN (229-695): 2.89e-55: 204: 14.52		EPN1_HUMAN (2-454): 2.23e-107: 331: 21.10
+	Mm
		1282818 EHD2_MOUSE (229-695): 1.08e-53: 200: 13.71		EPN1_MOUSE (2-454): 9.1e-109: 334: 21.75
+	Mm
		1362252 EHD1_MOUSE (232-689): 1.3e-55: 205: 15.40		EPN3_MOUSE (2-438): 5.95e-98: 308: 24.83
+	Ce
		1355818 Q8WSP1_CAEEL (232-696): 2.8e-54: 203: 15.49		Q9BI72_CAEEL (3-442): 1.97e-99: 307: 26.43
+	Mm
		1296578 EHD2_MOUSE (229-695): 1.08e-53: 200: 13.71		EPN3_MOUSE (2-438): 5.95e-98: 308: 24.83
+	Hs
		1458294 EP15R_HUMAN (129-540): 2.77e-27: 122: 17.22		EPN1_HUMAN (2-454): 2.23e-107: 331: 21.10
+	Sc
		739094 PAN1_YEAST (1-1475): 2.54e-103: 364: 100.00		ENT2_YEAST (340-447): 1.08e-16: 84.5: 75.00
+	Hs
		329453 ITSN1_HUMAN (44-382): 2.62e-29: 130: 16.57		EPN2_HUMAN (2-426): 2.31e-101: 317: 22.87
+	Mm
		1282821 ITSN1_MOUSE (251-1142): 3.38e-22: 106: 10.29		EPN1_MOUSE (2-454): 9.1e-109: 334: 21.75
+	Hs
		839821 EPS15_HUMAN (256-371): 2.28e-16: 87.3: 28.21		EPN3_HUMAN (2-435): 7.08e-108: 334: 26.02
+	Hs
		839851 EPS15_HUMAN (256-371): 2.28e-16: 87.3: 28.21		EPN1_HUMAN (2-454): 2.23e-107: 331: 21.10
+	Hs
		839761 EPS15_HUMAN (256-371): 2.28e-16: 87.3: 28.21		EPN4_HUMAN (3-442): 1.21e-104: 325: 18.93
+	Dm
		95607 E3CTP7_DROME (225-378): 1.29e-16: 87.9: 23.38		Q7KU90_DROME (5-446): 5.02e-91: 295: 25.71
+	Mm
		1455913 PCLO_MOUSE (1-1287): 7.5e-16: 86.1: 8.22		PCLO_MOUSE (131-449): 8.28e-38: 149: 12.12
+	Sp
		1082779 PAN1_SCHPO (1-1364): 1.11e-26: 121: 10.51		PAN1_SCHPO (233-447): 1.33e-09: 62.6: 11.93