HitPredict

Interactor 1: H2B1B (P33778)
Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f)
Gene: H2BC3

Interactor 2: HDAC6 (Q9UBN7)
Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	26643866, 37503842
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Hist_deacetyl~Histone
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 1215
+	Hs
		1408039 H2B1M_HUMAN (1-126): 5.09e-55: 169: 96.83		HDAC6_HUMAN (1-1215): 0: 1440: 100.00
+	Hs
		257009 H2B1K_HUMAN (1-126): 1.49e-54: 168: 96.83		HDAC6_HUMAN (1-1215): 0: 1440: 100.00
+	Hs
		946899 H2B1D_HUMAN (1-126): 2.9e-54: 167: 97.62		HDAC6_HUMAN (1-1215): 0: 1440: 100.00
+	Hs
		1408062 H2B1L_HUMAN (1-126): 3.03e-53: 164: 96.03		HDAC6_HUMAN (1-1215): 0: 1440: 100.00
+	Hs
		1109772 H2B2E_HUMAN (1-126): 7.07e-55: 169: 98.41		HDAC1_HUMAN (80-482): 4.66e-166: 503: 20.71
+	Hs
		754833 H2B1B_HUMAN (1-126): 1.31e-54: 168: 100.00		HDAC1_HUMAN (80-482): 4.66e-166: 503: 20.71
+	Hs
		980745 H2B1C_HUMAN (1-126): 1.28e-54: 168: 97.62		HDAC1_HUMAN (80-482): 4.66e-166: 503: 20.71
+	Hs
		1109889 H2B3B_HUMAN (1-126): 2.38e-52: 163: 96.03		HDAC1_HUMAN (80-482): 4.66e-166: 503: 20.71
+	Hs
		1163105 H2B2E_HUMAN (1-126): 7.07e-55: 169: 98.41		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Hs
		1368085 H2B1M_HUMAN (1-126): 5.09e-55: 169: 96.83		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Hs
		1109968 H2B1A_HUMAN (1-126): 8.06e-47: 148: 85.83		HDAC1_HUMAN (80-482): 4.66e-166: 503: 20.71
+	Hs
		754926 H2B1B_HUMAN (1-126): 1.31e-54: 168: 100.00		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Hs
		1368086 H2B1L_HUMAN (1-126): 3.03e-53: 164: 96.03		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Hs
		1323945 H2B3B_HUMAN (1-126): 2.38e-52: 163: 96.03		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Hs
		257017 H2B1K_HUMAN (1-126): 1.49e-54: 168: 96.83		HDAC5_HUMAN (33-471): 8.24e-146: 471: 32.48
+	Hs
		1368037 H2B1A_HUMAN (1-126): 8.06e-47: 148: 85.83		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Hs
		188336 H2B1A_HUMAN (1-126): 8.06e-47: 148: 85.83		HDAC3_HUMAN (479-890): 1.13e-146: 450: 18.29
+	Sc
		381589 H2B2_YEAST (3-125): 1.48e-40: 133: 70.73		HDA1_YEAST (80-456): 5.08e-148: 464: 33.17
+	Sc
		381204 H2B1_YEAST (3-125): 4.36e-36: 121: 70.73		HDA1_YEAST (80-456): 5.08e-148: 464: 33.17
+	Sc
		381020 H2B1_YEAST (3-125): 4.36e-36: 121: 70.73		RPD3_YEAST (83-473): 6.21e-150: 459: 20.63