HitPredict

Interactor 1: HCP3L (P34440)
Histone H3-like centromeric protein cpar-1 (CENP-A-related protein 1) (Centromeric protein A related)
Gene: cpar-1

Interactor 2: H4 (P62784)
Histone H4
Gene: his-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	18692475, unassigned701
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 261 Ce			1 103
+	Hs
		979480 H31_HUMAN (122-256): 7.17e-60: 187: 41.48		H4_HUMAN (1-103): 3.13e-48: 150: 99.03
+	Mm
		980639 H31_MOUSE (122-256): 7.17e-60: 187: 41.48		H4_MOUSE (1-103): 3.13e-48: 150: 99.03
+	Ce
		477116 H3_CAEEL (122-256): 2.36e-58: 183: 41.48		H4_CAEEL (1-103): 7.78e-49: 152: 100.00
+	Xl
		979441 H32_XENLA (122-256): 1.37e-58: 184: 42.22		H4_XENLA (1-103): 3.13e-48: 150: 99.03
+	Xl
		979443 Q92133_XENLA (122-256): 1.43e-58: 184: 42.22		H4_XENLA (1-103): 3.13e-48: 150: 99.03
+	Hs
		979499 H33_HUMAN (122-256): 1.01e-58: 184: 42.22		H4_HUMAN (1-103): 3.13e-48: 150: 99.03
+	Hs
		979874 H32_HUMAN (122-256): 1.37e-58: 184: 42.22		H4_HUMAN (1-103): 3.13e-48: 150: 99.03
+	Mm
		980642 H32_MOUSE (122-256): 1.37e-58: 184: 42.22		H4_MOUSE (1-103): 3.13e-48: 150: 99.03
+	Mm
		980643 H33_MOUSE (122-256): 1.01e-58: 184: 42.22		H4_MOUSE (1-103): 3.13e-48: 150: 99.03
+	Hs
		979740 H31T_HUMAN (122-256): 2.94e-58: 183: 40.00		H4_HUMAN (1-103): 3.13e-48: 150: 99.03
+	Hs
		979838 H3C_HUMAN (122-256): 2.87e-56: 178: 40.74		H4_HUMAN (1-103): 3.13e-48: 150: 99.03
+	Sp
		480419 H31_SCHPO (122-256): 2.31e-56: 178: 43.70		H4_SCHPO (18-103): 1.08e-41: 133: 88.37
+	Hs
		1258924 H32_HUMAN (122-256): 1.37e-58: 184: 42.22		H4G_HUMAN (1-98): 2.87e-38: 125: 83.67
+	Hs
		883497 CENPA_HUMAN (127-256): 4.73e-48: 157: 35.61		H4_HUMAN (1-103): 3.13e-48: 150: 99.03
+	Sc
		382276 H3_YEAST (122-256): 6.91e-53: 169: 40.00		H4_YEAST (18-103): 1.48e-40: 131: 89.54
+	Kl
		1231316 CENPA_KLULA (152-256): 4.96e-44: 148: 51.40		Q6CMU6_KLULA (18-103): 2.25e-41: 133: 90.70
+	Sc
		382025 CENPA_YEAST (162-256): 3.59e-20: 87.8: 52.63		H4_YEAST (18-103): 1.48e-40: 131: 89.54