HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: FBXW2 (Q9UKT8)
F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)
Gene: FBXW2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	30918250, 37820851
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 781 Hs			1 454
+	Hs
		765137 CTNB1_HUMAN (1-781): 0: 618: 100.00		FBW1A_HUMAN (24-313): 3.22e-59: 206: 18.03
+	Hs
		764947 CTNB1_HUMAN (1-781): 0: 618: 100.00		FBXW7_HUMAN (32-264): 1.01e-57: 203: 21.85
+	Mm
		1036055 CTNB1_MOUSE (1-781): 0: 616: 99.87		FBW1A_MOUSE (24-309): 1.71e-58: 203: 18.27
+	Xl
		1281796 Q7ZX35_XENLA (1-781): 0: 615: 97.31		TRCB_XENLA (24-309): 7.85e-58: 200: 18.61
+	Hs
		765100 CTNB1_HUMAN (1-781): 0: 618: 100.00		FBW1B_HUMAN (24-308): 4.55e-56: 196: 19.00
+	Hs
		261373 CTNB1_HUMAN (1-781): 0: 618: 100.00		TBL1X_HUMAN (220-452): 3.96e-32: 130: 15.23
+	Hs
		765015 CTNB1_HUMAN (1-781): 0: 618: 100.00		TBL1R_HUMAN (221-452): 9.21e-32: 128: 16.05
+	Hs
		764606 CTNB1_HUMAN (1-781): 0: 618: 100.00		WDR5_HUMAN (316-452): 5.63e-25: 106: 12.86
+	Hs
		577929 PLAK_HUMAN (8-752): 5.22e-156: 474: 67.42		FBW1A_HUMAN (24-313): 3.22e-59: 206: 18.03
+	Hs
		577844 PLAK_HUMAN (8-752): 5.22e-156: 474: 67.42		FBXW7_HUMAN (32-264): 1.01e-57: 203: 21.85
+	Dm
		616600 ARM_DROME (1-780): 1.45e-157: 480: 65.01		Q9VDE3_DROME (24-313): 1.13e-55: 194: 17.71
+	Hs
		577694 PLAK_HUMAN (8-752): 5.22e-156: 474: 67.42		WDR5_HUMAN (316-452): 5.63e-25: 106: 12.86
+	Ce
		1068782 BAR1_CAEEL (129-740): 4.74e-102: 334: 24.15		LIN23_CAEEL (24-254): 1.22e-32: 132: 16.07
+	Hs
		138739 IMA4_HUMAN (220-681): 9.14e-68: 234: 15.47		FBXW7_HUMAN (32-264): 1.01e-57: 203: 21.85
+	Hs
		911437 IMA5_HUMAN (240-678): 6.41e-66: 230: 16.44		FBW1A_HUMAN (24-313): 3.22e-59: 206: 18.03
+	Hs
		911426 IMA5_HUMAN (240-678): 6.41e-66: 230: 16.44		FBW1B_HUMAN (24-308): 4.55e-56: 196: 19.00
+	Hs
		222456 IMA5_HUMAN (240-678): 6.41e-66: 230: 16.44		PLRG1_HUMAN (78-350): 2.01e-43: 161: 18.49
+	Hs
		253674 IMA7_HUMAN (200-683): 1.75e-73: 250: 16.97		SNR40_HUMAN (129-253): 8.56e-12: 68.2: 31.25
+	Sc
		793977 IMA1_YEAST (219-692): 2.28e-69: 239: 15.26		TAF5_YEAST (163-259): 1.21e-14: 78.2: 39.22
+	Hs
		138742 IMA4_HUMAN (220-681): 9.14e-68: 234: 15.47		SNR40_HUMAN (129-253): 8.56e-12: 68.2: 31.25