HitPredict

Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 8995282
Identification Methods enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains IRS~IRS, IRS~PH, PH~PH
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 - protein kinase C binding
GO:0005158 - insulin receptor binding
GO:0005159 - insulin-like growth factor receptor binding
and 30 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 1242
Hs

1 1242
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Last updated: 11Aug2025